Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 10/20 | 0.36 |
| ▸ | KIT | P10721 | 2/20 | 0.34 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.31 |
| ▸ | AXL | P30530 | 2/20 | 0.30 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.30 |
| ▸ | MERTK | Q12866 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2592296 | 0.82 | MET (0.36) | METKITFLT3RIPK3LCK | |
| SCHEMBL16059291 | 0.79 | MET (0.35) | METKITFLT3RIPK3LCK | |
| SCHEMBL5154071 | 0.79 | MET (0.41) | METKITFLT3RIPK3LCK | |
| SCHEMBL5150627 | 0.77 | MET (0.39) | METKITFLT3RIPK3LCK | |
| SCHEMBL5150778 | 0.74 | MET (0.39) | METKITFLT3RIPK3LCK | |
| SCHEMBL1137048 | 0.73 | MET (0.40) | METKDRKDM4EAXLRAB9A | |
| SCHEMBL15542224 | 0.69 | MET (0.39) | METKITFLT3RIPK3LCK | |
| SCHEMBL5153188 | 0.69 | BRD4 (0.45) | MET | |
| SCHEMBL5186596 | 0.69 | MET (0.53) | METKDRAXL | |
| SCHEMBL10011418 | 0.66 | MET (0.59) | METKITFLT3RIPK3LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563773-A1 | PYRIDONE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITES | Deciphera Pharmaceuticals, LLC (US) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011139891-A1 | PYRIDONE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2011-11-10 | — | — | WO | disclosed |