⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27601050 | 0.67 | NOTUM (0.35) | — | |
| SCHEMBL14281827 | 0.67 | GAA (0.30) | — | |
| SCHEMBL4837604 | 0.62 | OXTR (0.31) | — | |
| SCHEMBL8183764 | 0.59 | — | — | |
| SCHEMBL30468123 | 0.55 | BRD4 (0.31) | — | |
| SCHEMBL224635 | 0.53 | ALOX5 (0.41) | — | |
| SCHEMBL30334802 | 0.52 | LMNA (0.43) | — | |
| SCHEMBL121647 | 0.52 | LMNA (0.43) | — | |
| SCHEMBL23876704 | 0.52 | ALOX5 (0.56) | — | |
| SCHEMBL19475848 | 0.52 | GAA (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970282-A1 | TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS | Incyte Corporation (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014143768-A1 | TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS | INCYTE CORPORATION (US) | 2014-09-18 | — | — | WO | disclosed |