SCHEMBL224635

SCHEMBL224635

C1=COc2ccccc2N1

nearest known ligand 0.41

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.41
PARP1 P09874 1/20 0.34
GAA P10253 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
LMNA P02545 2/20 0.31
CRHBP P24387 2/20 0.31
CRHR2 Q13324 2/20 0.31
SMN1; SMN2 Q16637 2/20 0.31
HTT P42858 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7159864 0.98 ALOX5 (0.39) ALOX5PARP1GAANPSR1LMNA
Hydrochloric Acid SCHEMBL6760431 0.98 ALOX5 (0.39) ALOX5PARP1GAANPSR1LMNA
Biphenyl SCHEMBL12979723 0.92 ALDH1A1 (0.36) ALOX5PARP1GAA
SCHEMBL18209132 0.90 ALOX5 (0.34) ALOX5PARP1
SCHEMBL7441406 0.87 ALOX5 (0.35) ALOX5PARP1
SCHEMBL1938607 0.87 ALOX5 (0.32) ALOX5
Trifluoroacetic Acid SCHEMBL2072797 0.82 CES1 (0.35) ALOX5
Trifluoroacetic Acid SCHEMBL2072798 0.82 CES1 (0.35) ALOX5
SCHEMBL5156 0.75
SCHEMBL7107394 0.74 POLB (0.36) GAANPSR1LMNAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 985 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12606767-B2 1,4-benzoxazine compounds and lubricant compositions containing the same THE LUBRIZOL CORPORATION (US) 2026-04-21 US claimed
EP-4377426-B1 1,4-BENZOXAZINE COMPOUNDS AND LUBRICANT COMPOSITIONS CONTAINING THE SAME LUBRIZOL CORP (US) 2026-04-15 EP claimed
WO-2025099111-A1 NEW TELESCOPING SYNTHESES OF 6-HYDROXY-BENZOMORPHOLINE (3,4-DIHYDRO-2H-1,4-BENZOXAZIN-6-OL) WELLA GERMANY GMBH (DE) 2025-05-15 WO claimed
US-20250115823-A1 1,4-Benzoxazine Compounds And Lubricant Compositions Containing The Same THE LUBRIZOL CORPORATION (US) 2025-04-10 US claimed
EP-4377426-A1 1,4-BENZOXAZINE COMPOUNDS AND LUBRICANT COMPOSITIONS CONTAINING THE SAME The Lubrizol Corporation (US) 2024-06-05 EP claimed
CN-117716007-A 1, 4-benzoxazine compound and lubricating oil composition containing 1, 4-benzoxazine compound 路博润公司 2024-03-15 CN claimed
WO-2023036995-A1 ALKYNYLCARBINOLS WITH HIGH CYTOTOXICITY CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2023-03-16 WO claimed
WO-2023009774-A1 1,4-BENZOXAZINE COMPOUNDS AND LUBRICANT COMPOSITIONS CONTAINING THE SAME THE LUBRIZOL CORPORATION (US) 2023-02-02 WO claimed
US-20230027198-A1 INHIBITORS OF ENL/AF9 YEATS THE ROCKEFELLER UNIVERSITY 2023-01-26 US claimed
US-20230015691-A1 PROPHYLACTIC OR THERAPEUTIC AGENT FOR NON-ALCOHOLIC STEATOHEPATITIS IN HUMANS MITSUBISHI TANABE PHARMA CORPORATION (JP) 2023-01-19 US claimed
EP-0245020-B1 PHOTOCHROMIC ARTICLES PILKINGTON PLC (GB) 1991-10-02 EP claimed
EP-0449669-A1 Photochromic compound, composition and use thereof TOKUYAMA CORPORATION (JP) 1991-10-02 EP claimed
EP-0197807-B1 PYRAZOLOBENZOXAZINE DERIVATIVES, THEIR SALTS, PROCESS AND PREPARATION INTERMEDIATES, USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM ROUSSEL-UCLAF (FR) 1990-04-18 EP claimed
US-4789675-A HYPOTENSIVE, ANTIISCHEMIC AGENTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1988-12-06 US claimed
EP-0094305-B1 9-OXALYSERGIC-ACID DERIVATIVES, THEIR SALTS, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, THEIR USE AS PHARMACEUTICAL PREPARATIONS AND COMPOSITIONS CONTAINING THEM ROUSSEL-UCLAF (FR) 1988-01-13 EP claimed
EP-0235043-A1 Tetrahydrobenz[c,d]indole derivatives, their salts, process for their preparation, their use as medicaments, compositions containing them, and intermediates ROUSSEL-UCLAF (FR) 1987-09-02 EP claimed
EP-0233728-A1 1,4-Benzoxazine derivatives their production and use Takeda Chemical Industries, Ltd. (JP) 1987-08-26 EP claimed
EP-0199543-A2 Heterocyclic amide derivatives ICI AMERICAS INC. (US) 1986-10-29 EP claimed
EP-0197807-A1 Pyrazolobenzoxazine derivatives, their salts, process and preparation intermediates, use as medicaments and compositions containing them ROUSSEL-UCLAF (FR) 1986-10-15 EP claimed
EP-0094305-A1 9-Oxalysergic-acid derivatives, their salts, process and intermediates for their preparation, their use as pharmaceutical preparations and compositions containing them ROUSSEL-UCLAF (FR) 1983-11-16 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230027198-A1 INHIBITORS OF ENL/AF9 YEATS MLLT3, YEATS2, MLLT1 ALOX5 752/4885PARP1 803/4885GAA 3726/4885
US-12606767-B2 1,4-benzoxazine compounds and lubricant compositions containing the same PRDX4, PRDX1, GPX4 ALOX5 305/4885PARP1 404/4885GAA 3997/4885
US-20250115823-A1 1,4-Benzoxazine Compounds And Lubricant Compositions Containing The Same PRDX4, PRDX1, PRDX2 ALOX5 148/4885PARP1 569/4885GAA 1662/4885
US-20230015691-A1 PROPHYLACTIC OR THERAPEUTIC AGENT FOR NON-ALCOHOLIC STEATOHEPATITIS IN HUMANS VCAM1, FABP1, ICAM1 ALOX5 1178/4885PARP1 783/4885GAA 2448/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.