Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.76 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.59 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | NT5E | P21589 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.54 |
| ▸ | PDE2A | O00408 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.54 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20820220 | 1.00 | HIF1A (0.76) | HIF1AALDH1A1ADORA2AADORA3ADORA2B | |
| SCHEMBL20820205 | 0.87 | ALDH1A1 (0.64) | HIF1AALDH1A1ADORA2AADORA3ADORA2B | |
| SCHEMBL16081109 | 0.87 | ALDH1A1 (0.64) | HIF1AALDH1A1ADORA2AADORA3ADORA2B | |
| Arazide SCHEMBL16569037 | 0.87 | ALDH1A1 (1.00) | HIF1AALDH1A1ADORA2AADORA3ADORA2B | |
| Arazide SCHEMBL14580416 | 0.87 | ALDH1A1 (1.00) | HIF1AALDH1A1ADORA2AADORA3ADORA2B | |
| Arazide SCHEMBL29533521 | 0.87 | ALDH1A1 (1.00) | HIF1AALDH1A1ADORA2AADORA3ADORA2B | |
| Arazide SCHEMBL20820203 | 0.87 | ALDH1A1 (1.00) | HIF1AALDH1A1ADORA2AADORA3ADORA2B | |
| Arazide SCHEMBL16081100 | 0.87 | ALDH1A1 (1.00) | HIF1AALDH1A1ADORA2AADORA3ADORA2B | |
| SCHEMBL24359132 | 0.84 | LMNA (0.78) | HIF1AADORA2AADORA3ADORA2BLMNA | |
| SCHEMBL22559823 | 0.84 | LMNA (0.78) | HIF1AADORA2AADORA3ADORA2BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160113956-A1 | AMINO ACID PHOSPHORAMIDATE PRONUCLEOTIDES OF 2'-CYANO, AZIDO AND AMINO NUCLEOSIDES FOR THE TREATMENT OF HCV | UNIVERSITE DE MONTPELLIER (FR) | 2016-04-28 | — | — | US | disclosed |
| US-20160113956-A1 | AMINO ACID PHOSPHORAMIDATE PRONUCLEOTIDES OF 2'-CYANO, AZIDO AND AMINO NUCLEOSIDES FOR THE TREATMENT OF HCV | UNIVERSITE DE MONTPELLIER (FR) | 2016-04-28 | — | — | US | disclosed |
| WO-2014160484-A1 | AMINO ACID PHOSPHORAMIDATE PRONUCLEOTIDES OF 2'-CYANO, AZIDO AND AMINO NUCLEOSIDES FOR THE TREATMENT OF HCV | IDENIX PHARMACEUTICALS, INC. (US) | 2014-10-02 | — | — | WO | disclosed |
| US-20140271547-A1 | AMINO ACID PHOSPHORAMIDATE PRONUCLEOTIDES OF 2'-CYANO, AZIDO AND AMINO NUCLEOSIDES FOR THE TREATMENT OF HCV | IDENIX PHARMACEUTICALS, INC. | 2014-09-18 | — | — | US | disclosed |
| US-20140271547-A1 | AMINO ACID PHOSPHORAMIDATE PRONUCLEOTIDES OF 2'-CYANO, AZIDO AND AMINO NUCLEOSIDES FOR THE TREATMENT OF HCV | IDENIX PHARMACEUTICALS, INC. | 2014-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160113956-A1 | AMINO ACID PHOSPHORAMIDATE PRONUCLEOTIDES OF 2'-CYANO, AZIDO AND AMINO NUCLEOSIDES FOR THE TREATMENT OF HCV | PNP, RNGTT, NSUN2 | HIF1A 3385/4885ALDH1A1 2764/4885ADORA2A 81/4885 |
| US-20140271547-A1 | AMINO ACID PHOSPHORAMIDATE PRONUCLEOTIDES OF 2'-CYANO, AZIDO AND AMINO NUCLEOSIDES FOR THE TREATMENT OF HCV | PNP, RNGTT, NSUN2 | HIF1A 3385/4885ALDH1A1 2764/4885ADORA2A 81/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.