Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16088283 | 0.86 | CSNK2A1 (0.46) | L3MBTL1RXFP1HSD17B1HSD17B2GAA | |
| SCHEMBL16084590 | 0.84 | FLT3 (0.34) | METALOX5APFEN1FLT3PIK3CA | |
| SCHEMBL16088273 | 0.82 | CAMK2D (0.33) | METALOX5APFEN1FLT3PIK3CA | |
| SCHEMBL15891392 | 0.79 | FYN (0.45) | RETFYNPIM1 | |
| SCHEMBL14848202 | 0.79 | TDP1 (0.45) | RETFYN | |
| SCHEMBL16154322 | 0.78 | CSNK2A1 (0.59) | L3MBTL1RXFP1HSD17B1HSD17B2GAA | |
| SCHEMBL17483266 | 0.76 | CSNK2A1 (0.47) | L3MBTL1RXFP1HSD17B1HSD17B2GAA | |
| SCHEMBL16154321 | 0.75 | CSNK2A1 (0.49) | L3MBTL1RXFP1HSD17B1HSD17B2GAA | |
| SCHEMBL17483265 | 0.75 | CSNK2A1 (0.43) | L3MBTL1RXFP1HSD17B1HSD17B2GAA | |
| SCHEMBL16088281 | 0.74 | NPY5R (0.37) | NPY5RFLT3PIK3CAPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970333-B1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | IPSEN PHARMA SAS (FR) | 2017-05-03 | — | — | EP | disclosed |
| US-9586975-B2 | Macrocyclic salt-inducible kinase inhibitors | ONCODESIGN S.A. (FR) | 2017-03-07 | — | — | US | disclosed |
| US-9586975-B2 | Macrocyclic salt-inducible kinase inhibitors | ONCODESIGN S.A. (FR) | 2017-03-07 | — | — | US | disclosed |
| US-20160031905-A1 | Macrocyclic LRRK2 Kinase Inhibitors | ONCODESIGN S.A. (FR) | 2016-02-04 | — | — | US | disclosed |
| US-20160031905-A1 | Macrocyclic LRRK2 Kinase Inhibitors | ONCODESIGN S.A. (FR) | 2016-02-04 | — | — | US | disclosed |
| US-20160024113-A1 | MACROCYCLIC SALT-INDUCIBLE KINASE INHIBITORS | ONCODESIGN S.A. (FR) | 2016-01-28 | — | — | US | disclosed |
| US-20160024113-A1 | MACROCYCLIC SALT-INDUCIBLE KINASE INHIBITORS | ONCODESIGN S.A. (FR) | 2016-01-28 | — | — | US | disclosed |
| WO-2014140235-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | IPSEN PHARMA S.A.S. (FR) | 2014-09-18 | — | — | WO | disclosed |
| WO-2014140313-A1 | MACROCYCLIC SALT-INDUCIBLE KINASE INHIBITORS | ONCODESIGN S.A. (FR) | 2014-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160024113-A1 | MACROCYCLIC SALT-INDUCIBLE KINASE INHIBITORS | SIK1, SIK3, SIK2 | L3MBTL1 1789/4885RXFP1 3871/4885HSD17B1 1622/4885 |
| US-20160031905-A1 | Macrocyclic LRRK2 Kinase Inhibitors | LRRK2, PINK1, PARK7 | L3MBTL1 680/4885RXFP1 4432/4885HSD17B1 4323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.