Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CCR3 | P51677 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.48 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PDE2A | O00408 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16087368 | 0.89 | KMT2A (0.59) | TDP1L3MBTL1CCR3HTTHPGD | |
| SCHEMBL16087385 | 0.86 | L3MBTL1 (0.66) | TDP1L3MBTL1SMN1; SMN2LMNAATM | |
| SCHEMBL16087283 | 0.82 | L3MBTL1 (0.63) | TDP1L3MBTL1SMN1; SMN2LMNAATM | |
| SCHEMBL16087187 | 0.82 | PKM (0.54) | TDP1L3MBTL1SMN1; SMN2LMNAATM | |
| SCHEMBL16087255 | 0.80 | KMT2A (0.53) | SMN1; SMN2ATMALDH1A1MEN1KMT2A | |
| SCHEMBL16087384 | 0.79 | L3MBTL1 (0.58) | TDP1L3MBTL1HTTSMN1; SMN2LMNA | |
| SCHEMBL16087362 | 0.79 | L3MBTL1 (0.54) | TDP1L3MBTL1CCR3SMN1; SMN2LMNA | |
| SCHEMBL16087358 | 0.78 | KMT2A (0.53) | TDP1L3MBTL1HTTSMN1; SMN2LMNA | |
| SCHEMBL14777810 | 0.78 | HCRTR1 (0.53) | L3MBTL1CCR3HTTSMN1; SMN2LMNA | |
| SCHEMBL6986208 | 0.77 | HPGD (0.71) | HTTHPGDDPP4DPP8SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2533782-B1 | PIPERAZINE DERIVATIVES FOR BLOCKING Cav2.2 CALCIUM CHANNELS | CONVERGENCE PHARMACEUTICALS (GB) | 2014-09-24 | — | — | EP | claimed |