Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | CD38 | P28907 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17622723 | 0.79 | AURKA (0.43) | SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL16090543 | 0.76 | ALDH1A1 (0.32) | ALDH1A1 | |
| SCHEMBL11105297 | 0.76 | GALR3 (0.60) | LMNASMN1; SMN2TP53RAB9AHSD17B10 | |
| SCHEMBL19957830 | 0.75 | CRHR1 (0.36) | LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL14983681 | 0.75 | YTHDC1 (0.44) | LMNAMAP4K4TP53HSD17B10ALDH1A1 | |
| SCHEMBL17623220 | 0.74 | TP53 (0.36) | LMNASMN1; SMN2HTTNPC1TP53 | |
| SCHEMBL22048110 | 0.73 | MEN1 (0.38) | LMNASMN1; SMN2HTTNPC1RAB9A | |
| SCHEMBL17623001 | 0.73 | PDE1B (0.30) | — | |
| SCHEMBL18708840 | 0.70 | LRRK2 (0.46) | LMNASMN1; SMN2HTTMAP4K4NPC1 | |
| SCHEMBL16090164 | 0.70 | KDM4E (0.43) | LMNASMN1; SMN2HTTMAP4K4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014144169-A1 | CARM1 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-09-18 | — | — | WO | disclosed |