Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 4/20 | 0.33 |
| ▸ | KDR | P35968 | 4/20 | 0.33 |
| ▸ | CA2 | P00918 | 3/20 | 0.33 |
| ▸ | CDK2 | P24941 | 3/20 | 0.33 |
| ▸ | CDK4 | P11802 | 2/20 | 0.33 |
| ▸ | CDK7 | P50613 | 2/20 | 0.33 |
| ▸ | CDK9 | P50750 | 2/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CCNH | P51946 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CXCR2 | P25025 | 3/20 | 0.31 |
| ▸ | CCR7 | P32248 | 1/20 | 0.31 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16091163 | 0.79 | TP53 (0.45) | ALDH1A1EGFRSMN1; SMN2TP53 | |
| SCHEMBL16090166 | 0.79 | LMNA (0.43) | ALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL17623220 | 0.77 | TP53 (0.36) | ALDH1A1SMN1; SMN2RPS6KB1TP53CYP1A2 | |
| SCHEMBL17623001 | 0.76 | PDE1B (0.30) | — | |
| SCHEMBL16091214 | 0.72 | AURKA (0.34) | AURKA | |
| SCHEMBL17623369 | 0.72 | RPS6KB1 (0.31) | RPS6KB1 | |
| SCHEMBL17623276 | 0.72 | TP53 (0.32) | TP53 | |
| SCHEMBL19957830 | 0.71 | CRHR1 (0.36) | SMN1; SMN2 | |
| SCHEMBL28681711 | 0.70 | GALR3 (0.61) | AURKAALDH1A1EGFRSMN1; SMN2CYP1A2 | |
| SCHEMBL28943346 | 0.70 | AURKA (0.40) | AURKAALDH1A1CDK1KDRCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016044641-A2 | CARM1 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2016-03-24 | — | — | WO | disclosed |