SCHEMBL160943

SCHEMBL160943

CN1CCc2ccc(Cl)cc2CC1

nearest known ligand 0.55

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 2/20 0.55
HTR2C P28335 2/20 0.55
HTR2B P41595 1/20 0.55
DRD2 P14416 10/20 0.55
DRD3 P35462 10/20 0.55
DRD1 P21728 9/20 0.55
DRD5 P21918 9/20 0.55
DRD4 P21917 5/20 0.53
CYP1A2 P05177 1/20 0.50
CYP3A4 P08684 1/20 0.50
CYP2D6 P10635 1/20 0.50
CYP2C9 P11712 1/20 0.50
CYP2C19 P33261 1/20 0.50
HTR6 P50406 1/20 0.50
MAOA P21397 1/20 0.48
MAOB P27338 1/20 0.48
NOTUM Q6P988 2/20 0.47
PNMT P11086 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6883015 0.94 MAOA (0.59) HTR2AHTR2CHTR2BDRD2DRD3
SCHEMBL29991420 0.92 MAOA (0.55) HTR2AHTR2CHTR2BDRD2DRD3
SCHEMBL2625798 0.92 MAOA (0.55) HTR2AHTR2CHTR2BDRD2DRD3
Nitric Acid SCHEMBL165780 0.86 HTR2A (0.50) HTR2AHTR2CHTR2BDRD2DRD3
SCHEMBL15962624 0.81
SCHEMBL2365814 0.81 HTR2A (0.53) HTR2AHTR2CHTR2BDRD2DRD3
SCHEMBL1905997 0.80 DRD2 (0.58) HTR2AHTR2CHTR2BDRD2DRD1
SCHEMBL2365665 0.80 DRD2 (0.47) HTR2AHTR2CDRD2DRD3DRD1
SCHEMBL15649743 0.79 MET (0.42) HTR2AHTR2CDRD2DRD3DRD1
Ammonia Solution, Strong SCHEMBL10465265 0.79 HTR2A (0.67) HTR2AHTR2CHTR2BPNMT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3328835-A1 5-HT2C RECEPTOR AGONISTS AND COMPOSITIONS AND METHODS OF USE Arena Pharmaceuticals, Inc. (US) 2018-06-06 EP disclosed
EP-3288946-A1 5-HT2C RECEPTOR AGONISTS AND COMPOSITIONS AND METHODS OF USE Arena Pharmaceuticals, Inc. (US) 2018-03-07 EP disclosed
WO-2017023679-A1 5-HT2C RECEPTOR AGONISTS AND COMPOSITIONS AND METHODS OF USE ARENA PHARMACEUTICALS, INC. (US) 2017-02-09 WO disclosed
WO-2016176177-A1 5-HT2C RECEPTOR AGONISTS AND COMPOSITIONS AND METHODS OF USE ARENA PHARMACEUTICALS, INC. (US) 2016-11-03 WO disclosed
EP-2939677-A1 ADMINISTRATION OF LORCASERIN TO INDVIDUALS WITH RENAL IMPAIRMENT Arena Pharmaceuticals, Inc. (US) 2015-11-04 EP disclosed
EP-2611449-A1 ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT Arena Pharmaceuticals, Inc. (US) 2013-07-10 EP disclosed
EP-2611781-A1 FAST-DISSOLVE DOSAGE FORMS OF 5-HT2C AGONISTS Arena Pharmaceuticals, Inc. (US) 2013-07-10 EP disclosed
EP-2611427-A2 MODIFIED-RELEASE DOSAGE FORMS OF 5-HT2C AGONISTS USEFUL FOR WEIGHT MANAGEMENT& xA; Arena Pharmaceuticals, Inc. (US) 2013-07-10 EP disclosed
CN-102648170-A Processes for the preparation of 5-HT2C receptor agonists ARENA PHARM INC 2012-08-22 CN disclosed
WO-2010148207-A3 PROCESSES FOR THE PREPARATION OF 5-HT2C RECEPTOR AGONISTS ARENA PHARMACEUTICALS, INC. (US) 2012-05-10 WO disclosed
WO-2010148207-A2 PROCESSES FOR THE PREPARATION OF 5-HT2C RECEPTOR AGONISTS ARENA PHARMACEUTICALS, INC. (US) 2010-12-23 WO disclosed
EP-2001852-A2 PROCESSES FOR THE PREPARATION OF 8-CHLORO-1-METHYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE AND INTERMEDIATES RELATED THERETO Arena Pharmaceuticals, Inc. (US) 2008-12-17 EP disclosed
WO-2007120517-A2 PROCESSES FOR THE PREPARATION OF 8-CHLORO-1-METHYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE AND INTERMEDIATES RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2007-10-25 WO disclosed
EP-1411881-A4 5HT sb 2C /sb RECEPTOR MODULATORS ARENA PHARM INC (US) 2004-07-07 EP disclosed
EP-1411881-A2 5HT sb 2C /sb RECEPTOR MODULATORS Arena Pharmaceuticals, Inc. (US) 2004-04-28 EP disclosed
WO-2003086306-A2 5HT2C RECEPTOR MODULATORS ARENA PHARMACEUTICALS, INC. (US) 2003-10-23 WO disclosed
EP-0080779-B1 3-BENZAZEPINES AS ALPHA-2 ANTAGONISTS SMITHKLINE BECKMAN CORPORATION (US) 1986-07-16 EP disclosed
US-4496558-A Pharmaceutical compositions and methods for producing alpha antagonism SMITHKLINE BECKMAN CORPORATION (US) 1985-01-29 US disclosed
EP-0108170-A1 3-Benzazepines as alpha-2 antagonists SMITHKLINE BECKMAN CORPORATION (US) 1984-05-16 EP disclosed
EP-0080779-A1 3-Benzazepines as alpha-2 antagonists SMITHKLINE BECKMAN CORPORATION (US) 1983-06-08 EP disclosed