Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.50 |
| ▸ | HTR2C | P28335 | 5/20 | 0.50 |
| ▸ | HTR2B | P41595 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 10/20 | 0.48 |
| ▸ | DRD3 | P35462 | 10/20 | 0.48 |
| ▸ | HTR6 | P50406 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 7/20 | 0.47 |
| ▸ | DRD5 | P21918 | 7/20 | 0.47 |
| ▸ | DRD4 | P21917 | 4/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL160943 | 0.86 | HTR2A (0.55) | HTR2AHTR2CHTR2BDRD2DRD3 | |
| SCHEMBL6883015 | 0.81 | MAOA (0.59) | HTR2AHTR2CHTR2BDRD2DRD3 | |
| SCHEMBL2625798 | 0.79 | MAOA (0.55) | HTR2AHTR2CHTR2BDRD2DRD3 | |
| SCHEMBL29991420 | 0.79 | MAOA (0.55) | HTR2AHTR2CHTR2BDRD2DRD3 | |
| SCHEMBL1950525 | 0.75 | PNMT (0.54) | HTR2AHTR2CHTR2BDRD1 | |
| SCHEMBL11068898 | 0.73 | NOTUM (0.59) | NOTUMMCHR1 | |
| SCHEMBL2365814 | 0.73 | HTR2A (0.53) | HTR2AHTR2CHTR2BDRD2DRD3 | |
| Aspartic Acid SCHEMBL165913 | 0.72 | SLC1A3 (0.48) | HTR2AHTR2CHTR2BDRD2DRD3 | |
| SCHEMBL10157047 | 0.71 | DRD1 (0.85) | DRD2DRD3DRD1DRD5DRD4 | |
| SCHEMBL20232216 | 0.71 | MAOA (0.50) | HTR2AHTR2CHTR2BDRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611449-A1 | ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT | Arena Pharmaceuticals, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030939-A1 | ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |