Setazindol

Setazindol

SCHEMBL160950

CNCc1ccccc1C(O)c1ccc(Cl)cc1

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 15/20 0.48
HTR2A P28223 3/20 0.48
SLC6A2 P23975 12/20 0.47
SLC6A3 Q01959 8/20 0.47
KCNH2 Q12809 5/20 0.42
CYP2D6 P10635 3/20 0.42
CYP3A4 P08684 2/20 0.42
OPRM1 P35372 1/20 0.39
OPRD1 P41143 1/20 0.39
OPRK1 P41145 1/20 0.39
OPRL1 P41146 1/20 0.39
CYP1A2 P05177 1/20 0.38
CYP2C19 P33261 1/20 0.38
BRD4 O60885 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28200881 0.87 MAPT (0.45) SLC6A4HTR2ASLC6A2SLC6A3KCNH2
SCHEMBL9666274 0.86 SLC6A2 (0.40) SLC6A4SLC6A2SLC6A3KCNH2CYP2D6
Hydrochloric Acid SCHEMBL28200249 0.85 MAPT (0.47) SLC6A4HTR2ASLC6A2SLC6A3KCNH2
SCHEMBL9663611 0.84 ALDH1A1 (0.46) SLC6A4HTR2ASLC6A2SLC6A3KCNH2
SCHEMBL9665191 0.82 MEN1 (0.49) SLC6A4HTR2ASLC6A2SLC6A3CYP2D6
SCHEMBL9666074 0.81 OPRM1 (0.49) SLC6A4HTR2ASLC6A2SLC6A3KCNH2
SCHEMBL9666286 0.80 SMN1; SMN2 (0.46) SLC6A4SLC6A2SLC6A3CYP2D6CYP1A2
SCHEMBL9463489 0.80 SLC6A2 (0.47) SLC6A4SLC6A2SLC6A3CYP3A4OPRM1
SCHEMBL9664389 0.78 SLC6A4 (0.72) SLC6A4HTR2ASLC6A2SLC6A3
SCHEMBL24497314 0.74 SLC6A4 (0.40) SLC6A4HTR2ASLC6A2SLC6A3KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 154 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3366306-A2 USE OF SOME PEPTIDES IN DIAGNOSIS AND TREATMENT OF DIABETES, OBESITY AND METABOLIC DISEASES ASSOCIATED THERETO Istanbul Universitesi Rektorlugu (TR) 2018-08-29 EP claimed
EP-3351262-A1 CURAGLUTIDE FOR IN TREATMENT OF PREDIABETES, DIABETES, OBESITY AND METABOLIC DISEASES ASSOCIATED THERETO Istanbul Universitesi Rektorlugu (TR) 2018-07-25 EP claimed
EP-2961730-A2 METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS XenoPort, Inc. (US) 2016-01-06 EP claimed
US-20150158809-A9 METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS XENOPORT, INC. (US) 2015-06-11 US claimed
WO-2014134005-A2 METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS XENOPORT, INC. (US) 2014-09-04 WO claimed
US-20140243544-A1 METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS XENOPORT, INC. (US) 2014-08-28 US claimed
CN-101486668-B Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof XENOPORT INC 2014-07-02 CN claimed
US-8299291-B2 Methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs XENOPORT, INC. (US) 2012-10-30 US claimed
US-8062870-B2 Enantiomerically resolving acyloxyalkyl thiocarbonates used in synthesizing acyloxyalkyl carbamate prodrugs XENOPORT, INC. (US) 2011-11-22 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
US-5028630-A Benzylamines BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 1991-07-02 US claimed
EP-2841109-B1 PRODRUGS OF HYDROXYL-COMPRISING DRUGS ASCENDIS PHARMA AS (DK) 2026-04-15 EP disclosed
EP-3782649-B1 BIODEGRADABLE POLYETHYLENE GLYCOL BASED WATER-INSOLUBLE HYDROGELS ASCENDIS PHARMA AS (DK) 2025-05-14 EP disclosed
US-20230381323-A1 RELEASABLE CONJUGATES FISH & RICHARDSON PC 2023-11-30 US disclosed
US-11786599-B2 Releasable conjugates QUIAPEG PHARMACEUTICALS AB (SE) 2023-10-17 US disclosed
US-6264917-B1 MIXTURE OF GAS FILLED MICROBUBBLES AND RELEASING AGENT NYCOMED IMAGING AS (NO) 2001-07-24 US disclosed
US-6261537-B1 TARGETS AND ULTRASOUND DIAGNOSIS OF ACTIVE MATERIALS, AQUEOUS CARRIER LIQUIDS, CARRIERS AND FILM FORMING SURFACTANT PHOSPHATIDES NYCOMED IMAGING AS (NO) 2001-07-17 US disclosed
US-5162371-A Benzylamine Devivatives BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 1992-11-10 US disclosed
US-5028630-A Benzylamines BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 1991-07-02 US disclosed
US-4444778-A ANTISEROTONINE AGENTS COUGHLIN SHAUN R 1984-04-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150158809-A9 METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS CPS1, CA7, NAAA SLC6A4 1081/4885HTR2A 2235/4885SLC6A2 999/4885
US-20230381323-A1 RELEASABLE CONJUGATES GUSB, ABCB11, UGT2B7 SLC6A4 1369/4885HTR2A 2530/4885SLC6A2 361/4885
US-20140243544-A1 METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS CPS1, CA7, NAAA SLC6A4 1081/4885HTR2A 2235/4885SLC6A2 999/4885
US-11786599-B2 Releasable conjugates GUSB, ABCB11, UGT2B7 SLC6A4 1369/4885HTR2A 2530/4885SLC6A2 361/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.