Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.36 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16095836 | 0.90 | PHF8 (0.39) | LMNAMAPTADORA2AADORA1KDM4C | |
| SCHEMBL16095914 | 0.82 | MAPK14 (0.50) | MAPTKDM4CMAPK14TGFBR1 | |
| SCHEMBL16095079 | 0.79 | ADORA2A (0.39) | LMNAMAPTKDM4EADORA2AADORA1 | |
| SCHEMBL16095271 | 0.76 | NPY5R (0.34) | KDM4CMAPK14METAP2METAP1TGFBR1 | |
| SCHEMBL16094449 | 0.75 | USP30 (0.36) | MAPK14METAP2METAP1 | |
| SCHEMBL16095177 | 0.75 | KDM4C (0.39) | LMNAMAPTADORA2AADORA1KDM4C | |
| SCHEMBL16095105 | 0.74 | MAPK14 (0.46) | KDM4CPHF8MAPK14 | |
| SCHEMBL16033536 | 0.73 | PHF8 (0.60) | KDM4CPHF8VNN1MAPK14TSHR | |
| SCHEMBL17604545 | 0.72 | NPY5R (0.37) | KDM4CMETAP2METAP1 | |
| SCHEMBL16033852 | 0.72 | PHF8 (0.51) | KDM4CPHF8VNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2969007-A1 | HISTONE DEMETHYLASE INHIBITORS | Quanticel Pharmaceuticals Inc (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014151945-A1 | HISTONE DEMETHYLASE INHIBITORS | Quanticel Pharmaceuticals, Inc. (US) | 2014-09-25 | — | — | WO | disclosed |