Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MC4R | P32245 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CCR6 | P51684 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22973514 | 0.82 | AKT1 (0.42) | DRD2DRD3AKT1OPRM1OPRD1 | |
| SCHEMBL460703 | 0.77 | ALDH1A1 (0.34) | ALDH1A1LMNAMGLLFAAHPTGS1 | |
| SCHEMBL16097118 | 0.75 | MGLL (0.46) | ALDH1A1LMNAHSP90AA1PKMHTT | |
| SCHEMBL16195830 | 0.75 | MGLL (0.46) | ALDH1A1LMNAHSP90AA1PKMHTT | |
| Trifluoroacetic Acid SCHEMBL22973513 | 0.73 | DRD2 (0.47) | DRD2DRD3AKT1OPRM1OPRD1 | |
| SCHEMBL16307668 | 0.72 | SMN1; SMN2 (0.49) | DRD3AKT1OPRM1OPRD1OPRK1 | |
| SCHEMBL12094240 | 0.72 | ALDH1A1 (0.48) | DRD2DRD3AKT1OPRM1OPRD1 | |
| Trifluoroacetic Acid SCHEMBL16095879 | 0.71 | DRD2 (0.46) | DRD2DRD3AKT1OPRM1OPRD1 | |
| SCHEMBL26971749 | 0.71 | MGLL (0.42) | DRD2DRD3AKT1OPRM1OPRD1 | |
| SCHEMBL13093320 | 0.70 | MGLL (0.43) | AKT1OPRM1OPRD1OPRK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11833215-B2 | CKIT antibody drug conjugates | NOVARTIS AG (CH) | 2023-12-05 | — | — | US | disclosed |
| US-20200405875-A1 | CKIT ANTIBODY DRUG CONJUGATES | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2020-12-31 | — | — | US | disclosed |
| WO-2016020791-A1 | CKIT ANTIBODY DRUG CONJUGATES | NOVARTIS AG (CH) | 2016-02-11 | — | — | WO | disclosed |
| EP-2968591-A1 | CELL PROLIFERATION INHIBITORS AND CONJUGATES THEREOF | Novartis AG (CH) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014151030-A1 | CELL PROLIFERATION INHIBITORS AND CONJUGATES THEREOF | NOVARTIS AG (CH) | 2014-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200405875-A1 | CKIT ANTIBODY DRUG CONJUGATES | EPCAM, CD44, CKAP4 | DRD2 4052/4885DRD3 3276/4885AKT1 4241/4885 |
| US-11833215-B2 | CKIT antibody drug conjugates | EPCAM, CD44, CKAP4 | DRD2 4052/4885DRD3 3276/4885AKT1 4241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.