Sugi Predict

Sugi Predict / Compounds / SCHEMBL160980

SCHEMBL160980

SCHEMBL160980

Cc1cccc(Cl)c1N=C=O

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GABRA1 P14867 2/20 0.52
▸ GABRB2 P47870 2/20 0.52
▸ CYP3A4 P08684 2/20 0.45
▸ TDP1 Q9NUW8 2/20 0.38
▸ MAPK1 P28482 1/20 0.38
▸ HSP90AA1 P07900 2/20 0.38
▸ MAPT P10636 2/20 0.38
▸ ALDH1A1 P00352 2/20 0.38
▸ TRPA1 O75762 1/20 0.36
▸ MEN1 O00255 4/20 0.34
▸ KMT2A Q03164 4/20 0.34
▸ ATM Q13315 1/20 0.34
▸ HDAC4 P56524 1/20 0.32
▸ PBRM1 Q86U86 1/20 0.32
▸ GRIA1 P42261 1/20 0.32
▸ CACNG8 Q8WXS5 1/20 0.32
▸ TYK2 P29597 1/20 0.32
▸ PARP1 P09874 1/20 0.32
▸ GAA P10253 1/20 0.32
▸ KDM4E B2RXH2 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30390691 1.00 GABRA1 (0.52) GABRA1GABRB2CYP3A4TDP1MAPK1
SCHEMBL374209 0.85 GABRA1 (0.56) GABRA1GABRB2CYP3A4TDP1HSP90AA1
SCHEMBL326586 0.85 GABRA1 (0.56) GABRA1GABRB2CYP3A4TDP1MAPK1
SCHEMBL11429288 0.83 MEN1 (0.36) GABRA1GABRB2HSP90AA1MAPTALDH1A1
SCHEMBL27818899 0.82 MEN1 (0.35) GABRA1GABRB2CYP3A4HSP90AA1MAPT
SCHEMBL9643667 0.82 GABRA1 (0.44) GABRA1GABRB2CYP3A4TDP1MAPK1
SCHEMBL1457069 0.80 GABRA1 (0.50) GABRA1GABRB2CYP3A4TDP1HSP90AA1
SCHEMBL3635498 0.79 GABRA1 (0.50) GABRA1GABRB2CYP3A4TDP1MAPK1
SCHEMBL1133364 0.79 GABRA1 (0.50) GABRA1GABRB2CYP3A4HSP90AA1ALDH1A1
SCHEMBL28201284 0.79 GABRA1 (0.50) GABRA1GABRB2CYP3A4TDP1HSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 270 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119306449-B High-strength ecological environment-friendly water permeable brick and preparation method thereof 山东招和环保建材有限责任公司 2025-02-25 — — CN claimed
CN-119306449-A High-strength ecological environment-friendly water permeable brick and preparation method thereof 山东招和环保建材有限责任公司 2025-01-14 — — CN claimed
US-20070249823-A1 PROCESS FOR PREPARING GEMCITABINE AND ASSOCIATED INTERMEDIATES CHEMAGIS LTD. (IL) 2007-10-25 — — US claimed
WO-2007070804-A2 PROCESS FOR PREPARING GEMCITABINE AND ASSOCIATED INTERMEDIATES CHEMAGIS LTD. (IL) 2007-06-21 — — WO claimed
EP-1754705-A2 Antagonists for treatment of CD11/CD18 adhesion receptor mediated disorders Genentech, Inc. (US) 2007-02-21 — — EP claimed
EP-1377589-B1 OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS PHARMACIA ITALIA SPA (IT) 2005-09-07 — — EP claimed
US-6019925-A TERTIARY AMINE OXIDE AKZO NOBEL NV (NL) 2000-02-01 — — US claimed
CN-117886824-B 2, 3-Dihydropyrimido [4,5-d ] pyrimidine-4 (1H) -ketone derivative, preparation method and application thereof 四川大学华西医院 2026-05-15 — — CN disclosed
US-20250223263-A1 SELECTIVE INHIBITORS OF NLRP3 INFLAMMASOME NodThera Limited (GB) 2025-07-10 — — US disclosed
US-12304913-B2 Dihydropyrrolopyrazole derivative UBE INDUSTRIES, LTD. (JP) 2025-05-20 — — US disclosed
US-12247011-B2 Selective inhibitors of NLRP3 inflammasome NodThera Limited (GB) 2025-03-11 — — US disclosed
CN-119306449-B High-strength ecological environment-friendly water permeable brick and preparation method thereof 山东招和环保建材有限责任公司 2025-02-25 — — CN disclosed
CN-119306449-B High-strength ecological environment-friendly water permeable brick and preparation method thereof 山东招和环保建材有限责任公司 2025-02-25 — — CN disclosed
US-4265900-A HYPOTENSIVE, ANTISECRETORY, ANTIDIARRHEA MCNEILAB, INC. (US) 1981-05-05 — — US disclosed
US-4239768-A GASTROINTESTINAL DISORDERS MCNEILAB, INC. (US) 1980-12-16 — — US disclosed
US-4229462-A N-ARYL-N'-(2-IMIDAZOLIDINYLIDENE)UREA MCNEILAB, INC. (US) 1980-10-21 — — US disclosed
US-4224242-A ANTI-ARRHYTHMIC AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1980-09-23 — — US disclosed
US-4046909-A Pyrrolidylidene, piperidylidene and hexahydroazepinylidene ureas as CNS depressants MCNEIL LABORATORIES, INCORPORATED (US) 1977-09-06 — — US disclosed
US-3998958-A Pyrrolidylidene, piperidylidene and hexahydroazepinylidene ureas as CNS depressants MCNEIL LABORATORIES, INCORPORATED (US) 1976-12-21 — — US disclosed
US-3976785-A Dioxocyclohexanecarboxanilide insecticides and acaricides AMERICAN CYANAMID COMPANY (US) 1976-08-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12247011-B2 Selective inhibitors of NLRP3 inflammasome NLRP3, NOD1, NLRP1 GABRA1 2922/4885GABRB2 2882/4885CYP3A4 2832/4885
US-20250223263-A1 SELECTIVE INHIBITORS OF NLRP3 INFLAMMASOME NLRP3, NOD1, NLRP1 GABRA1 2922/4885GABRB2 2882/4885CYP3A4 2832/4885
US-20070249823-A1 PROCESS FOR PREPARING GEMCITABINE AND ASSOCIATED INTERMEDIATES DPYD, PARP1, PARP2 GABRA1 4343/4885GABRB2 4255/4885CYP3A4 535/4885
US-12304913-B2 Dihydropyrrolopyrazole derivative CBR3, SLC13A3, CYP3A5 GABRA1 704/4885GABRB2 1057/4885CYP3A4 18/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.