Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP6 | P55212 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
| ▸ | HCAR3 | P49019 | 12/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1609389 | 0.98 | CASP6 (0.64) | CASP6TSHRHCAR3POLBLMNA | |
| SCHEMBL17399916 | 0.89 | CASP6 (0.60) | CASP6TSHRHCAR3POLBLMNA | |
| SCHEMBL18027781 | 0.86 | CASP6 (0.66) | CASP6TSHRHCAR3POLBLMNA | |
| SCHEMBL12775960 | 0.86 | KMT2A (0.60) | CASP6TSHRPOLBLMNAKMT2A | |
| SCHEMBL20757 | 0.86 | PDK1 (0.68) | CASP6TSHRHCAR3LMNAKMT2A | |
| SCHEMBL10757957 | 0.86 | HCAR3 (0.58) | CASP6TSHRHCAR3POLBLMNA | |
| SCHEMBL1609387 | 0.85 | PDK1 (0.54) | CASP6TSHRHCAR3POLBLMNA | |
| SCHEMBL15174048 | 0.85 | CASP6 (0.64) | CASP6TSHRHCAR3POLBLMNA | |
| SCHEMBL7643058 | 0.85 | CASP6 (0.64) | CASP6TSHRHCAR3POLBLMNA | |
| SCHEMBL8096019 | 0.85 | PDK1 (0.50) | CASP6TSHRHCAR3POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2311792-B1 | Friedel-Crafts acylation for synthesis of aryl and heteroaryl-(3-ethyl-4-nitro-phenyl)-methanones | ROCHE DIAGNOSTICS GMBH (DE) | 2013-05-15 | — | — | EP | claimed |
| EP-2311792-A1 | Friedel-Crafts acylation for synthesis of aryl and heteroaryl-(3-ethyl-4-nitro-phenyl)-methanones | Roche Diagnostics GmbH (DE) | 2011-04-20 | — | — | EP | claimed |
| US-20110087013-A1 | Friedel-Crafts acylation for the synthesis of aryl- and heteroaryl-(3-ethyl-4-nitrophenyl)-methanones | ROCHE NIMBLEGEN, INC. | 2011-04-14 | — | — | US | claimed |
| CN-105085406-A | Benzimidazole ring-containing propiolamide derivative, preparation method, pharmaceutical composition and application thereof | INST MATERIA MEDICA CAMS | 2015-11-25 | — | — | CN | disclosed |
| EP-2311792-B1 | Friedel-Crafts acylation for synthesis of aryl and heteroaryl-(3-ethyl-4-nitro-phenyl)-methanones | ROCHE DIAGNOSTICS GMBH (DE) | 2013-05-15 | — | — | EP | disclosed |
| EP-2311792-B1 | Friedel-Crafts acylation for synthesis of aryl and heteroaryl-(3-ethyl-4-nitro-phenyl)-methanones | ROCHE DIAGNOSTICS GMBH (DE) | 2013-05-15 | — | — | EP | disclosed |
| EP-2311792-A1 | Friedel-Crafts acylation for synthesis of aryl and heteroaryl-(3-ethyl-4-nitro-phenyl)-methanones | Roche Diagnostics GmbH (DE) | 2011-04-20 | — | — | EP | disclosed |
| EP-2311792-A1 | Friedel-Crafts acylation for synthesis of aryl and heteroaryl-(3-ethyl-4-nitro-phenyl)-methanones | Roche Diagnostics GmbH (DE) | 2011-04-20 | — | — | EP | disclosed |
| EP-2311792-A1 | Friedel-Crafts acylation for synthesis of aryl and heteroaryl-(3-ethyl-4-nitro-phenyl)-methanones | Roche Diagnostics GmbH (DE) | 2011-04-20 | — | — | EP | disclosed |
| US-20110087013-A1 | Friedel-Crafts acylation for the synthesis of aryl- and heteroaryl-(3-ethyl-4-nitrophenyl)-methanones | ROCHE NIMBLEGEN, INC. | 2011-04-14 | — | — | US | disclosed |
| US-20110087013-A1 | Friedel-Crafts acylation for the synthesis of aryl- and heteroaryl-(3-ethyl-4-nitrophenyl)-methanones | ROCHE NIMBLEGEN, INC. | 2011-04-14 | — | — | US | disclosed |
| US-4705861-A | AZO DYE CHEMICAL INTERMEDIATES | BAYER AKTIENGESELLSCHAFT (DE) | 1987-11-10 | — | — | US | disclosed |
| EP-0187231-A2 | Amino phenyl benzothiazoles | BAYER AG (DE) | 1986-07-16 | — | — | EP | disclosed |
| EP-0001246-B1 | PREPARATION OF 2-(3'- OR 4'-AMINOPHENYL)-5(OR 6)-AMINOBENZIMIDAZOLES | CASSELLA Aktiengesellschaft (DE) | 1981-02-25 | — | — | EP | disclosed |
| US-4192947-A | REACTING DIAMINO NITROBENZENE WITH NITROBENZOYL CHLORIDE, CYCLIZING ANILIDE IN AQUEOUS ALKALI, REDUCING NITRO GROUPS WITH SULFIDE | CASSELLA AKTIENGESELLSCHAFT (DE) | 1980-03-11 | — | — | US | disclosed |
| EP-0001246-A1 | Preparation of 2-(3'- or 4'-aminophenyl)-5(or 6)-aminobenzimidazoles | CASSELLA Aktiengesellschaft (DE) | 1979-04-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110087013-A1 | Friedel-Crafts acylation for the synthesis of aryl- and heteroaryl-(3-ethyl-4-nitrophenyl)-methanones | CYP2B6, HNF4A, AHR | CASP6 155/4885TSHR 3890/4885HCAR3 773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.