Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 3/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29455965 | 1.00 | ERN1 (0.41) | ERN1DGAT1TUBB1NPC1RAB9A | |
| SCHEMBL16100599 | 0.86 | MAPT (0.44) | ERN1DGAT1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20607683 | 0.86 | ERN1 (0.42) | ERN1DGAT1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29456087 | 0.86 | MAPT (0.44) | ERN1DGAT1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16101039 | 0.84 | DGAT1 (0.41) | ERN1DGAT1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16101138 | 0.84 | MAPK14 (0.40) | ERN1DGAT1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL462096 | 0.83 | HTR1A (0.37) | ERN1DGAT1TUBB1NPC1RAB9A | |
| SCHEMBL7097452 | 0.79 | ERN1 (0.50) | ERN1TUBB1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3543787 | 0.78 | ERN1 (0.47) | ERN1TUBB1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL26133310 | 0.78 | DGAT1 (0.48) | ERN1DGAT1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113563368-A | Boron-containing small molecules | 比尔及梅琳达盖茨基金会 | 2021-10-29 | — | — | CN | disclosed |
| CN-113321672-A | Boron-containing small molecules | 比尔及梅琳达盖茨基金会 | 2021-08-31 | — | — | CN | disclosed |
| EP-3423065-B1 | BORON-CONTAINING SMALL MOLECULES | ANACOR PHARMACEUTICALS INC (US) | 2021-07-21 | — | — | EP | disclosed |
| CN-109195608-B | Boron-containing small molecules | 比尔及梅琳达盖茨基金会 | 2021-05-11 | — | — | CN | disclosed |
| US-10919916-B2 | Boron-containing small molecules | BILL & MELINDA GATES FOUNDATION (US) | 2021-02-16 | — | — | US | disclosed |
| US-20200247827-A1 | BORON-CONTAINING SMALL MOLECULES | BILL & MELINDA GATES FOUNDATION (US) | 2020-08-06 | — | — | US | disclosed |
| US-10611780-B2 | Boron-containing small molecules | BILL AND MELINDA GATES FOUNDATION (US) | 2020-04-07 | — | — | US | disclosed |
| US-20190077814-A1 | BORON-CONTAINING SMALL MOLECULES | GATES FOUNDATION | 2019-03-14 | — | — | US | disclosed |
| EP-3423065-A1 | BORON-CONTAINING SMALL MOLECULES | Anacor Pharmaceuticals, Inc. (US) | 2019-01-09 | — | — | EP | disclosed |
| EP-2970339-B1 | 1-HYDROXY-BENZOOXABOROLES AS ANTIPARASITIC AGENTS | LILLY CO ELI (US) | 2017-08-16 | — | — | EP | disclosed |
| US-9617285-B2 | 1-hydroxy-benzooxaboroles as antiparasitic agents | ELI LILLY AND COMPANY (US) | 2017-04-11 | — | — | US | disclosed |
| EP-2970339-A1 | 1 -HYDROXY-BENZOOXABOROLES AS ANTIPARASITIC AGENTS | Eli Lilly and Company (US) | 2016-01-20 | — | — | EP | disclosed |
| US-20150353581-A1 | 1-HYDROXY-BENZOOXABOROLES AS ANTIPARASITIC AGENTS | ELI LILLY AND COMPANY (US) | 2015-12-10 | — | — | US | disclosed |
| WO-2014149793-A1 | 1 -HYDROXY-BENZOOXABOROLES AS ANTIPARASITIC AGENTS | ELI LILLY AND COMPANY (US) | 2014-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190077814-A1 | BORON-CONTAINING SMALL MOLECULES | BCL6B, BLVRB, BTD | ERN1 2674/4885DGAT1 4625/4885TUBB1 290/4885 |
| US-20150353581-A1 | 1-HYDROXY-BENZOOXABOROLES AS ANTIPARASITIC AGENTS | HAO1, CYP8B1, KMO | ERN1 3051/4885DGAT1 2685/4885TUBB1 373/4885 |
| US-10919916-B2 | Boron-containing small molecules | BCL6B, BLVRB, BTD | ERN1 2674/4885DGAT1 4625/4885TUBB1 290/4885 |
| US-10611780-B2 | Boron-containing small molecules | BCL6B, BLVRB, BTD | ERN1 2674/4885DGAT1 4625/4885TUBB1 290/4885 |
| US-20200247827-A1 | BORON-CONTAINING SMALL MOLECULES | BCL6B, BLVRB, BTD | ERN1 2674/4885DGAT1 4625/4885TUBB1 290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.