SCHEMBL16100756

SCHEMBL16100756

COCOc1cc(C=CC(=O)c2c(O)cccc2OCOC)ccc1OC

nearest known ligand 0.61

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAOB P27338 4/20 0.61
MAOA P21397 3/20 0.61
BACE1 P56817 2/20 0.61
ABCG2 Q9UNQ0 3/20 0.58
ACHE P22303 1/20 0.57
CYP3A4 P08684 1/20 0.55
CXCL12 P48061 1/20 0.55
NFKB1 P19838 3/20 0.55
NFKB2 Q00653 3/20 0.55
RELA Q04206 3/20 0.55
PDE4A P27815 1/20 0.54
PDE4B Q07343 1/20 0.54
PDE4C Q08493 1/20 0.54
PDE4D Q08499 1/20 0.54
AURKA O14965 1/20 0.53
NR1H4 Q96RI1 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30383246 1.00 MAOB (0.61) MAOBMAOABACE1ABCG2ACHE
SCHEMBL30384157 1.00 MAOB (0.61) MAOBMAOABACE1ABCG2ACHE
SCHEMBL16098173 1.00 MAOB (0.61) MAOBMAOABACE1ABCG2ACHE
SCHEMBL31088177 0.93 BACE1 (0.56) MAOBMAOABACE1ABCG2ACHE
SCHEMBL31088175 0.93 BACE1 (0.56) MAOBMAOABACE1ABCG2ACHE
SCHEMBL16490919 0.87 MAOB (0.74) MAOBMAOAABCG2ACHECYP3A4
SCHEMBL30384092 0.87 MAOB (0.74) MAOBMAOAABCG2ACHECYP3A4
SCHEMBL30383843 0.87 MAOB (0.74) MAOBMAOAABCG2ACHECYP3A4
SCHEMBL19182752 0.87 MAOB (0.74) MAOBMAOAABCG2ACHECYP3A4
SCHEMBL31088178 0.85 ABCG2 (0.69) MAOBMAOAABCG2CYP3A4NFKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 US disclosed
US-20250134146-A1 FLAVANONE COMPOUNDS AND THEIR USE AS FLAVOR MODIFIERS FIRMENICH INCORPORATED (US) 2025-05-01 US disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 WO disclosed
EP-2984077-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING SWEET TASTE Chromocell Corporation (US) 2016-02-17 EP disclosed
US-20160015064-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING SWEET TASTE CHROMOCELL CORPORATION (US) 2016-01-21 US disclosed
US-20150050410-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING SWEET TASTE CHROMOCELL CORPORATION (US) 2015-02-19 US disclosed
WO-2014153000-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING SWEET TASTE CHROMOCELL CORPORATION (US) 2014-09-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150050410-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING SWEET TASTE TAS2R5, TAS2R20, TAS2R10 MAOB 4493/4885MAOA 4572/4885BACE1 3415/4885
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B MAOB 1004/4885MAOA 1902/4885BACE1 712/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 MAOB 2435/4885MAOA 3145/4885BACE1 1486/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 MAOB 2435/4885MAOA 3145/4885BACE1 1486/4885
US-20160015064-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING SWEET TASTE TAS2R5, TAS2R20, TAS2R10 MAOB 4493/4885MAOA 4572/4885BACE1 3415/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.