Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | ILK | Q13418 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.32 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.32 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.32 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.32 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.32 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.32 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.32 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16068634 | 0.71 | PRKAB2 (0.32) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL22572979 | 0.63 | AOC3 (0.39) | GAAPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL14833240 | 0.63 | GAA (0.44) | MAPTGAAMTOR | |
| SCHEMBL4016705 | 0.62 | DAO (0.47) | HCAR2LRRK2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL1988296 | 0.62 | KDM5B (0.37) | MAPK1PIK3CBPRKAB2PRKAG1PRKAA2 | |
| SCHEMBL16940980 | 0.59 | HCAR2 (0.47) | HCAR2 | |
| SCHEMBL1559055 | 0.58 | IRAK4 (0.33) | — | |
| SCHEMBL2945106 | 0.58 | PDE8B (0.35) | MTOR | |
| SCHEMBL21001231 | 0.57 | MAOA (0.39) | — | |
| SCHEMBL30168873 | 0.57 | MAOA (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180186751-A1 | HALOGENOPYRAZOLES AS INHIBITORS OF THROMBIN | VERSEON INTERNATIONAL CORPORATION | 2018-07-05 | — | — | US | disclosed |
| US-9951025-B2 | Halogenopyrazoles as inhibitors of thrombin | VERSEON CORPORATION (US) | 2018-04-24 | — | — | US | disclosed |
| US-20160046585-A1 | HALOGENOPYRAZOLES AS INHIBITORS OF THROMBIN | VERSEON INTERNATIONAL CORPORATION | 2016-02-18 | — | — | US | disclosed |
| EP-2970141-A2 | HALOGENOPYRAZOLES AS INHIBITORS OF THROMBIN | Verseon Corporation (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014149139-A2 | HALOGENOPYRAZOLES AS INHIBITORS OF THROMBIN | VERSEON, INC. (US) | 2014-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180186751-A1 | HALOGENOPYRAZOLES AS INHIBITORS OF THROMBIN | F2, TFPI, SERPINC1 | HCAR2 3034/4885MAPT 3276/4885GAA 1578/4885 |
| US-20160046585-A1 | HALOGENOPYRAZOLES AS INHIBITORS OF THROMBIN | F2, TFPI, SERPINC1 | HCAR2 3034/4885MAPT 3276/4885GAA 1578/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.