Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SCN4A | P35499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL968221 | 0.90 | GAA (0.44) | GAAMAPTPOLBALDH1A1THRB | |
| SCHEMBL21486892 | 0.81 | GAA (0.35) | GAAMAPTPOLBALDH1A1THRB | |
| SCHEMBL29778859 | 0.81 | CA1 (0.42) | GAAMAPTPOLBALDH1A1THRB | |
| SCHEMBL19643366 | 0.81 | CA1 (0.42) | GAAMAPTPOLBALDH1A1THRB | |
| SCHEMBL14676282 | 0.81 | CA1 (0.42) | GAAMAPTPOLBALDH1A1THRB | |
| SCHEMBL21603490 | 0.81 | PTGS1 (0.34) | GAAMAPTPOLBALDH1A1THRB | |
| SCHEMBL23796403 | 0.77 | ALDH1A1 (0.33) | GAAPOLBALDH1A1THRBFFAR4 | |
| SCHEMBL24058054 | 0.77 | POLB (0.33) | GAAPOLBALDH1A1THRBL3MBTL1 | |
| SCHEMBL23796052 | 0.77 | GAA (0.36) | GAAPOLBALDH1A1THRBNPC1 | |
| SCHEMBL30443190 | 0.77 | POLB (0.33) | GAAPOLBALDH1A1THRBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627652-B1 | PYRIDYL BENZOXAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND USE THEREOF | DAE WOONG PHARMA (KR) | 2015-12-16 | — | — | EP | disclosed |
| CN-103153990-B | Novel pyridyl benzoxazine derivatives, pharmaceutical composition comprising the same, and use thereof | DAE WOONG PHARMA | 2015-06-17 | — | — | CN | disclosed |
| CN-101983197-B | A novel benzoxazine benzimidazole derivative, a pharmaceutical composition comprising the same, and a use thereof | DAE WOONG PHARMA | 2015-04-22 | — | — | CN | disclosed |
| EP-2264031-B1 | A NOVEL BENZOXAZINE BENZIMIDAZOLE DERIVATIVE, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND A USE THEREOF | DAE WOONG PHARMA (KR) | 2015-04-15 | — | — | EP | disclosed |
| EP-2627652-A2 | NOVEL PYRIDYL BENZOXAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND USE THEREOF | Daewoong Pharmaceutical Co., Ltd (KR) | 2013-08-21 | — | — | EP | disclosed |
| US-8362012-B2 | Benzoxazine benzimidazole derivative, a pharmaceutical composition comprising the same, and a use thereof | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2013-01-29 | — | — | US | disclosed |
| WO-2012050380-A2 | NOVEL PYRIDYL BENZOXAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND USE THEREOF | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2012-04-19 | — | — | WO | disclosed |
| US-8026235-B1 | Pyridyl benzoxazine derivatives, pharmaceutical composition comprising the same, and use thereof | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2011-09-27 | — | — | US | disclosed |
| WO-2011097491-A1 | BENZIMIDAZOLE ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2011-08-11 | — | — | WO | disclosed |
| US-20110086849-A1 | NOVEL BENZOXAZINE BENZIMIDAZOLE DERIVATIVE, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND AUSE THEREOF | DAEWOONG PHARMACEUTICALS CO., LTD. (KR) | 2011-04-14 | — | — | US | disclosed |
| EP-2264031-A2 | A NOVEL BENZOXAZINE BENZIMIDAZOLE DERIVATIVE, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND A USE THEREOF | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2010-12-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086849-A1 | NOVEL BENZOXAZINE BENZIMIDAZOLE DERIVATIVE, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND AUSE THEREOF | TRPV1, HRH4, TRPV4 | GAA 1928/4885MAPT 4710/4885POLB 4804/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.