Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 3/20 | 0.42 |
| ▸ | CTSS | P25774 | 3/20 | 0.42 |
| ▸ | CTSB | P07858 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6135327 | 0.85 | HTT (0.58) | SMN1; SMN2LMNAKCNA5HTTKMT2A | |
| SCHEMBL1610723 | 0.83 | SMN1; SMN2 (0.51) | SMN1; SMN2LMNAKCNA5HTTL3MBTL1 | |
| SCHEMBL21985416 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2LMNAKCNA5HTTMEN1 | |
| SCHEMBL292084 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2LMNAKCNA5HTTMEN1 | |
| SCHEMBL13741500 | 0.79 | SMN1; SMN2 (0.59) | SMN1; SMN2LMNAHTTMEN1KMT2A | |
| SCHEMBL19527405 | 0.79 | SMN1; SMN2 (0.52) | SMN1; SMN2LMNAKCNA5HTTL3MBTL1 | |
| SCHEMBL25448079 | 0.78 | PPID (0.46) | SMN1; SMN2LMNAKCNA5HTTL3MBTL1 | |
| SCHEMBL18002248 | 0.78 | SMN1; SMN2 (0.58) | SMN1; SMN2LMNAHTTMEN1KMT2A | |
| SCHEMBL16368616 | 0.77 | SMN1; SMN2 (0.51) | SMN1; SMN2LMNAKCNA5HTTMEN1 | |
| SCHEMBL25281617 | 0.77 | HTT (0.59) | SMN1; SMN2LMNAKCNA5HTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110086893-A1 | OXA- AND THIADIAZOLES AND THEIR USE AS METALLOPROTEINASE INHIBITORS | VERNALIS (OXFORD) LTD (GB) | 2011-04-14 | — | — | US | disclosed |
| CN-100351245-C | Oxa- and thiadiazoles and their use as metalloproteinase inhibitors | VERNALIS OXFORD LTD (GB) | 2007-11-28 | — | — | CN | disclosed |
| CN-1646505-A | Oxa- and thiadiazoles and their use as metalloproteinase inhibitors | VERNALIS OXFORD LTD (GB) | 2005-07-27 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086893-A1 | OXA- AND THIADIAZOLES AND THEIR USE AS METALLOPROTEINASE INHIBITORS | MMP12, TIMP3, MMP9 | SMN1; SMN2 3288/4885LMNA 4112/4885KCNA5 4177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.