SCHEMBL16110397

SCHEMBL16110397

CCC1(c2ccc(C)cc2)OC1C(=O)OC(C)(C)C

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 1/20 0.33
MAPK1 P28482 1/20 0.32
ABHD10 Q9NUJ1 1/20 0.32
OPRM1 P35372 1/20 0.32
NPBWR1 P48145 1/20 0.31
MCHR1 Q99705 1/20 0.31
PPARG P37231 1/20 0.31
PPARA Q07869 1/20 0.31
HSD11B1 P28845 1/20 0.31
HPGD P15428 1/20 0.31
KMT2A Q03164 2/20 0.30
ADORA2B P29275 1/20 0.30
NFKB1 P19838 1/20 0.30
NFKB2 Q00653 1/20 0.30
RELA Q04206 1/20 0.30
MMP13 P45452 1/20 0.30
GAA P10253 2/20 0.30
MEN1 O00255 1/20 0.30
RAB9A P51151 1/20 0.30
LMNA P02545 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14967326 0.87 ABCB1 (0.37) MAPK1KMT2AMEN1
SCHEMBL14967598 0.86 ELANE (0.36) MAPK1PPARGPPARAHSD11B1HPGD
SCHEMBL16109613 0.84 LMNA (0.39) OPRM1HPGDKMT2AGAAMEN1
SCHEMBL9692237 0.84 TDP1 (0.36) ABHD10OPRM1HPGDKMT2AGAA
SCHEMBL16110272 0.81 ABHD10 (0.44) ABHD10OPRM1HSD11B1KMT2AADORA2B
SCHEMBL16110563 0.81 ALDH1A1 (0.34) ABHD10OPRM1HPGDKMT2AADORA2B
SCHEMBL14967609 0.80 GPR119 (0.35) GPR119MAPK1NPBWR1MCHR1HSD11B1
SCHEMBL16109685 0.80 SCN1A (0.36) OPRM1HSD11B1KMT2AMEN1RAB9A
SCHEMBL16108688 0.78 USP2 (0.36) PPARGHSD11B1KMT2AMEN1RAB9A
SCHEMBL16108654 0.78 TSHR (0.37) MAPK1PPARGKMT2AMEN1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10301397-B2 Method for producing polydienes and polydiene copolymers with reduced cold flow BRIDGESTONE CORPORATION (JP) 2019-05-28 US disclosed
US-20160340447-A1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW BRIDGESTONE CORPORATION (JP) 2016-11-24 US disclosed
US-9458270-B2 Method for producing polydienes and polydiene copolymers with reduced cold flow BRIDGESTONE CORPORATION (JP) 2016-10-04 US disclosed
EP-2780177-B1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW BRIDGESTONE CORP (JP) 2016-03-23 EP disclosed
US-20140296445-A1 Method For Producing Polydienes And Polydiene Copolymers With Reduced Cold Flow BRIDGESTONE CORPORATION (JP) 2014-10-02 US disclosed