Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | TYMP | P19971 | 3/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TNKS | O95271 | 2/20 | 0.36 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GPR3 | P46089 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16669006 | 0.75 | ALDH1A1 (0.33) | ALDH1A1HSD17B10GPR3 | |
| SCHEMBL12004982 | 0.75 | ALOX5 (0.45) | PARP1KDM4EGSK3BMEN1LMNA | |
| SCHEMBL790633 | 0.75 | KDM4E (0.42) | PARP1KDM4ECA12CA9GSK3B | |
| SCHEMBL15009544 | 0.69 | ALDH1A1 (0.61) | PARP1KDM4ECA12CA9MEN1 | |
| SCHEMBL38236 | 0.68 | KDM4E (0.48) | PARP1KDM4ECA12CA9TYMP | |
| SCHEMBL5030 | 0.67 | ALDH1A1 (0.54) | PARP1KDM4ECA12CA9MEN1 | |
| SCHEMBL6313741 | 0.67 | GRIN2D (0.52) | PARP1KDM4ECA12CA9MEN1 | |
| Benzoylenurea SCHEMBL37945 | 0.66 | KDM4E (1.00) | PARP1KDM4ECA12CA9MEN1 | |
| Benzoylenurea SCHEMBL29407209 | 0.66 | KDM4E (1.00) | PARP1KDM4ECA12CA9MEN1 | |
| SCHEMBL5652739 | 0.65 | AHR (0.47) | KDM4EALDH1A1POLBMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180273508-A1 | THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. | 2018-09-27 | — | — | US | disclosed |
| US-20140303164-A1 | THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. | 2014-10-09 | — | — | US | disclosed |
| US-20140296266-A1 | THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. | 2014-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296266-A1 | THERAPEUTIC COMPOUNDS | HAVCR2, SARS1, G6PD | PARP1 2578/4885KDM4E 4478/4885CA12 3256/4885 |
| US-20180273508-A1 | THERAPEUTIC COMPOUNDS | HAVCR2, SARS1, RPL35 | PARP1 2482/4885KDM4E 4453/4885CA12 3388/4885 |
| US-20140303164-A1 | THERAPEUTIC COMPOUNDS | HAVCR2, SARS1, G6PD | PARP1 2578/4885KDM4E 4478/4885CA12 3256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.