Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16111260 | 0.84 | TSHR (0.44) | TSHRMGAMGAASIMGAM2 | |
| SCHEMBL13698867 | 0.79 | TSHR (0.43) | TSHRMGAMGAASIMGAM2 | |
| SCHEMBL16111259 | 0.78 | TSHR (0.46) | TSHRMGAMGAASIMGAM2 | |
| SCHEMBL15550819 | 0.77 | TSHR (0.44) | TSHRMGAMGAASIMGAM2 | |
| SCHEMBL7943512 | 0.75 | TSHR (0.43) | TSHRMGAMGAASIMGAM2 | |
| SCHEMBL13698866 | 0.75 | TSHR (0.43) | TSHRMGAMGAASIMGAM2 | |
| SCHEMBL20094580 | 0.74 | ALDH1A1 (0.37) | TSHRLMNAALDH1A1HSD17B10 | |
| SCHEMBL16110875 | 0.71 | TSHR (0.43) | TSHRMGAMGAASIMGAM2 | |
| SCHEMBL16111475 | 0.70 | — | — | |
| SCHEMBL25285768 | 0.68 | TSHR (0.48) | TSHRKMT2AMEN1LMNACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970172-B1 | BICYCLO [2.2.2]ACID GPR120 MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2019-10-30 | — | — | EP | disclosed |
| EP-2970172-B1 | BICYCLO [2.2.2]ACID GPR120 MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2019-10-30 | — | — | EP | disclosed |
| US-9598390-B2 | Bicyclo[2.2.2]acid GPR120 modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-03-21 | — | — | US | disclosed |
| US-9598390-B2 | Bicyclo[2.2.2]acid GPR120 modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-03-21 | — | — | US | disclosed |
| US-9598390-B2 | Bicyclo[2.2.2]acid GPR120 modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-03-21 | — | — | US | disclosed |
| US-20160039780-A1 | BICYCLO [2.2.2] ACID GPR120 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-02-11 | — | — | US | disclosed |
| US-20160039780-A1 | BICYCLO [2.2.2] ACID GPR120 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-02-11 | — | — | US | disclosed |
| US-20160039780-A1 | BICYCLO [2.2.2] ACID GPR120 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-02-11 | — | — | US | disclosed |
| EP-2970172-A1 | BICYCLO [2.2.2]ACID GPR120 MODULATORS | Bristol-Myers Squibb Company (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014159802-A1 | BICYCLO [2.2.2] ACID GPR120 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-10-02 | — | — | WO | disclosed |
| WO-2014159802-A1 | BICYCLO [2.2.2] ACID GPR120 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160039780-A1 | BICYCLO [2.2.2] ACID GPR120 MODULATORS | GPR180, GPR88, GPBAR1 | TSHR 1001/4885MGAM 3419/4885GAA 3774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.