Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | FPR3 | P25089 | 3/20 | 0.36 |
| ▸ | FPR2 | P25090 | 3/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26981939 | 0.89 | NPSR1 (0.48) | SMN1; SMN2MEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL21777896 | 0.87 | MAPT (0.46) | RORCSMN1; SMN2MEN1KMT2ACYP2C19 | |
| SCHEMBL26981951 | 0.84 | ALDH1A1 (0.41) | RORCSMN1; SMN2MEN1KMT2ACYP2C19 | |
| SCHEMBL30069764 | 0.84 | ALDH1A1 (0.41) | RORCSMN1; SMN2MEN1KMT2ACYP2C19 | |
| SCHEMBL16111612 | 0.79 | ALDH1A1 (0.43) | SMN1; SMN2MEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL21778061 | 0.79 | SMN1; SMN2 (0.50) | SMN1; SMN2MEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL16112128 | 0.77 | MEN1 (0.39) | SMN1; SMN2MEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL15549442 | 0.75 | FPR2 (0.53) | MEN1KMT2AMAPK1ALDH1A1LMNA | |
| SCHEMBL429816 | 0.74 | MEN1 (0.39) | SMN1; SMN2MEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL21777929 | 0.73 | EPHX2 (0.43) | SMN1; SMN2ALDH1A1NPSR1GPR119P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014160649-A1 | HYDROXAMIC ACID DERIVATIVES AS LPXC INHIBITORS FOR THE TREATMENT OF BACTERIAL INFECTIONS | NOVARTIS AG (CH) | 2014-10-02 | — | — | WO | disclosed |
| WO-2014160649-A1 | HYDROXAMIC ACID DERIVATIVES AS LPXC INHIBITORS FOR THE TREATMENT OF BACTERIAL INFECTIONS | NOVARTIS AG (CH) | 2014-10-02 | — | — | WO | disclosed |