Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | PARP1 | P09874 | 3/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PREP | P48147 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26981951 | 1.00 | ALDH1A1 (0.41) | ALDH1A1PARP1GPR119DPP4JAK2 | |
| SCHEMBL26981939 | 0.86 | NPSR1 (0.48) | ALDH1A1MEN1KMT2ASMN1; SMN2CYP2C19 | |
| SCHEMBL21777896 | 0.84 | MAPT (0.46) | ALDH1A1GPR119RORCMEN1KMT2A | |
| SCHEMBL16112282 | 0.84 | RORC (0.40) | ALDH1A1GPR119JAK2JAK1RORC | |
| SCHEMBL26981991 | 0.79 | JAK2 (0.43) | PARP1GPR119DPP4JAK2JAK1 | |
| SCHEMBL26981981 | 0.77 | RIPK1 (0.38) | ALDH1A1PARP1DPP4JAK2JAK1 | |
| SCHEMBL21778061 | 0.76 | SMN1; SMN2 (0.50) | ALDH1A1MEN1KMT2ASMN1; SMN2CYP2C19 | |
| SCHEMBL30764762 | 0.73 | PARP1 (0.48) | PARP1GPR119DPP4JAK2JAK1 | |
| SCHEMBL26982000 | 0.72 | USP30 (0.47) | ALDH1A1GPR119SMN1; SMN2CYP2C19HTT | |
| SCHEMBL429816 | 0.71 | MEN1 (0.39) | ALDH1A1MEN1KMT2ASMN1; SMN2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4301760-A1 | CARDIAC SARCOMERE INHIBITORS | Cytokinetics, Inc. (US) | 2024-01-10 | — | — | EP | disclosed |
| WO-2022187501-A1 | CARDIAC SARCOMERE INHIBITORS | CYTOKINETICS, INC. (US) | 2022-09-09 | — | — | WO | disclosed |