Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.43 |
| ▸ | RPA1 | P27694 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 2/20 | 0.39 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.39 |
| ▸ | SGK1 | O00141 | 1/20 | 0.39 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16111747 | 0.85 | LMNA (0.48) | HTTFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL30590681 | 0.80 | FGFR1 (0.46) | HTTFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL3493408 | 0.77 | HTT (0.46) | HTTLMNAALDH1A1SMN1; SMN2NR4A2 | |
| SCHEMBL26553256 | 0.77 | LMNA (0.48) | HTTLMNAALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL5769402 | 0.74 | CA12 (0.44) | HTTALDH1A1SGK1CAMKK2KMT2A | |
| SCHEMBL30590618 | 0.72 | HTT (0.43) | HTTLMNAALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL1127735 | 0.70 | HTT (0.54) | HTTFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL12658127 | 0.70 | NR4A2 (0.57) | HTTLMNAALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL8319411 | 0.70 | LMNA (0.51) | HTTFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL16112586 | 0.70 | ALDH1A1 (0.46) | HTTFGFR1FGFR2FGFR4FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014159214-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI FOUNDATION, INC. (US) | 2014-10-02 | — | — | WO | disclosed |