Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4062743 | 0.79 | AXL (0.32) | APPAXLNUDT1 | |
| SCHEMBL25523073 | 0.72 | ALOX5AP (0.41) | AXLNUDT1 | |
| SCHEMBL5355503 | 0.72 | JAK1 (0.42) | — | |
| SCHEMBL30406662 | 0.72 | ALOX5AP (0.41) | AXLNUDT1 | |
| SCHEMBL5873715 | 0.68 | — | — | |
| SCHEMBL28298844 | 0.67 | AXL (0.33) | APPAXLNUDT1 | |
| SCHEMBL31251321 | 0.67 | FAAH (0.36) | AXLNUDT1 | |
| SCHEMBL8609416 | 0.66 | TNKS (0.38) | APP | |
| SCHEMBL6674240 | 0.63 | TYR (0.40) | — | |
| SCHEMBL5336883 | 0.61 | MEN1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970299-A1 | PYRROLOPYRIMINDINE CDK9 KINASE INHIBITORS | Abbvie Inc. (US) | 2016-01-20 | — | — | EP | claimed |
| WO-2014160028-A1 | PYRROLOPYRIMINDINE CDK9 KINASE INHIBITORS | ABBVIE INC. (US) | 2014-10-02 | — | — | WO | claimed |
| EP-2970299-A1 | PYRROLOPYRIMINDINE CDK9 KINASE INHIBITORS | Abbvie Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014160028-A1 | PYRROLOPYRIMINDINE CDK9 KINASE INHIBITORS | ABBVIE INC. (US) | 2014-10-02 | — | — | WO | disclosed |