⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11540135 | 0.71 | RECQL (0.38) | — | |
| SCHEMBL5336883 | 0.70 | MEN1 (0.42) | — | |
| SCHEMBL4169709 | 0.69 | SLC18A3 (0.42) | — | |
| SCHEMBL6652929 | 0.69 | CDC7 (0.32) | — | |
| SCHEMBL16620559 | 0.68 | HTR1A (0.32) | — | |
| Hydrochloric Acid SCHEMBL947630 | 0.67 | — | — | |
| SCHEMBL18895032 | 0.67 | DCPS (0.42) | — | |
| SCHEMBL10990208 | 0.65 | KDM4E (0.31) | — | |
| SCHEMBL19814462 | 0.64 | KDM4E (0.32) | — | |
| SCHEMBL655217 | 0.63 | HTR3A (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0976745-B1 | 4-TETRAHYDROPYRIDYLPYRIMIDINE DERIVATIVES | TAISHO PHARMACEUTICAL CO LTD (JP) | 2003-08-13 | — | — | EP | claimed |
| US-6187781-B1 | CORTICOTROPIN RELEASING FACTOR RECEPTOR ANTAGONISTS; ALZHEIMER*S, HUNTINGTON, AND PARKINSON DISEASE; ANTIDEPRESSANTS, ANXIOLYTIC AGENTS | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2001-02-13 | — | — | US | claimed |
| EP-0976745-A1 | 4-TETRAHYDROPYRIDYLPYRIMIDINE DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2000-02-02 | — | — | EP | claimed |
| US-7084156-B2 | 2-Aminoquinoline compounds | MERCK & CO., INC. (US) | 2006-08-01 | — | — | US | disclosed |
| EP-1451156-A4 | 4-AMINOQUINOLINE COMPOUNDS | MERCK & CO INC (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2005035526-A1 | BICYCLIC COMPOUNDS AND THEIR THERAPEUTIC USE | ARGENTA DISCOVERY LTD. (GB) | 2005-04-21 | — | — | WO | disclosed |
| WO-2005035521-A1 | SUBSTITUTED QUINOLINES AS MCR MODULATORS | ARGENTA DISCOVERY LTD. (GB) | 2005-04-21 | — | — | WO | disclosed |
| US-20050026915-A1 | 2-Aminoquinoline compounds | MERCK SHARP & DOHME CORP. | 2005-02-03 | — | — | US | disclosed |
| EP-1450801-A2 | 2-AMINOQUINOLINE COMPOUNDS | Merck & Co., Inc. (US) | 2004-09-01 | — | — | EP | disclosed |
| EP-1451156-A1 | 4-AMINOQUINOLINE COMPOUNDS | Merck & Co., Inc. (US) | 2004-09-01 | — | — | EP | disclosed |
| CN-1142931-C | 4-tetrahydropyridylpyrimidine derivatives | ������ҩ��ʽ���� | 2004-03-24 | — | — | CN | disclosed |
| US-6187781-B1 | CORTICOTROPIN RELEASING FACTOR RECEPTOR ANTAGONISTS; ALZHEIMER*S, HUNTINGTON, AND PARKINSON DISEASE; ANTIDEPRESSANTS, ANXIOLYTIC AGENTS | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| US-6187781-B1 | CORTICOTROPIN RELEASING FACTOR RECEPTOR ANTAGONISTS; ALZHEIMER*S, HUNTINGTON, AND PARKINSON DISEASE; ANTIDEPRESSANTS, ANXIOLYTIC AGENTS | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| US-6187781-B1 | CORTICOTROPIN RELEASING FACTOR RECEPTOR ANTAGONISTS; ALZHEIMER*S, HUNTINGTON, AND PARKINSON DISEASE; ANTIDEPRESSANTS, ANXIOLYTIC AGENTS | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| CN-1257491-A | 4-tetrahydropyridylpyrimidine derivatives | TAISHO PHARMACEUTICAL CO LTD (JP) | 2000-06-21 | — | — | CN | disclosed |
| CN-1257491-A | 4-tetrahydropyridylpyrimidine derivatives | TAISHO PHARMACEUTICAL CO LTD (JP) | 2000-06-21 | — | — | CN | disclosed |
| JP-2000063277-A | CRF RECEPTOR ANTAGONIST | TAISHO PHARMACEUT CO LTD | 2000-02-29 | — | — | JP | disclosed |
| EP-0976745-A1 | 4-TETRAHYDROPYRIDYLPYRIMIDINE DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2000-02-02 | — | — | EP | disclosed |
| EP-0976745-A1 | 4-TETRAHYDROPYRIDYLPYRIMIDINE DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998042699-A1 | 4-TETRAHYDROPYRIDYLPYRIMIDINE DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 1998-10-01 | — | — | WO | disclosed |