Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5355503 | 0.73 | JAK1 (0.42) | JAK2JAK1 | |
| SCHEMBL30406662 | 0.73 | ALOX5AP (0.41) | AXLNUDT1JAK2JAK1 | |
| SCHEMBL25523073 | 0.73 | ALOX5AP (0.41) | AXLNUDT1JAK2JAK1 | |
| SCHEMBL4062743 | 0.69 | AXL (0.32) | AXLNUDT1APPCDK8 | |
| SCHEMBL31251321 | 0.68 | FAAH (0.36) | AXLNUDT1JAK2JAK1PIK3CD | |
| SCHEMBL16113191 | 0.67 | APP (0.32) | AXLNUDT1APP | |
| SCHEMBL167083 | 0.64 | AXL (0.42) | AXLNUDT1APPCDK8PIK3CD | |
| SCHEMBL1442938 | 0.64 | AXL (0.42) | AXLNUDT1APPCDK8JAK2 | |
| SCHEMBL29755564 | 0.64 | ULK1 (0.43) | AXLNUDT1CDK8PIK3CDPIK3CA | |
| SCHEMBL15917037 | 0.64 | MAPK1 (0.47) | AXLNUDT1APPCDK8JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109789135-A | ISOQUINOLINE DERIVATIVES AS PERK INHIBITORS | 葛兰素史密斯克莱知识产权发展有限公司 | 2019-05-21 | — | — | CN | disclosed |