Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | OGA | O60502 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 4/20 | 0.38 |
| ▸ | ATRIP | Q8WXE1 | 3/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5873715 | 0.70 | — | — | |
| SCHEMBL21711099 | 0.69 | PIK3CA (0.50) | MEN1USP2ALDH1A1CYP1A2ALOX15 | |
| SCHEMBL5457199 | 0.67 | PIK3CA (0.55) | MEN1USP2ALDH1A1CYP1A2ALOX15 | |
| SCHEMBL244876 | 0.66 | HRH3 (0.65) | MEN1USP2ALDH1A1CYP1A2ALOX15 | |
| SCHEMBL21914804 | 0.66 | PIK3CA (0.50) | MEN1USP2ALDH1A1CYP1A2ALOX15 | |
| SCHEMBL29790016 | 0.66 | PIK3CA (0.50) | MEN1USP2ALDH1A1CYP1A2ALOX15 | |
| SCHEMBL1110658 | 0.66 | PIK3CA (0.50) | MEN1USP2ALDH1A1CYP1A2ALOX15 | |
| SCHEMBL13033968 | 0.66 | KMT2A (0.57) | MEN1USP2ALDH1A1CYP1A2ALOX15 | |
| SCHEMBL9678255 | 0.65 | OGA (0.59) | MEN1USP2ALDH1A1CYP1A2ALOX15 | |
| SCHEMBL5485306 | 0.64 | PIK3CA (0.49) | MEN1USP2ALDH1A1CYP1A2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007066103-A1 | PYRIMIDINE DERIVATIVES AS CLASS I PI3K INHIBITOR | ASTRAZENECA AB (SE) | 2007-06-14 | — | — | WO | claimed |
| WO-2007066103-A1 | PYRIMIDINE DERIVATIVES AS CLASS I PI3K INHIBITOR | ASTRAZENECA AB (SE) | 2007-06-14 | — | — | WO | disclosed |