Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2C
The experimentally established mechanism targets of Oxymetazoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 6/20 | 0.97 |
| ▸ | ADRA2B known ✓ | P18089 | 5/20 | 0.97 |
| ▸ | ADRA2C known ✓ | P18825 | 5/20 | 0.97 |
| ▸ | ADRA1D known ✓ | P25100 | 5/20 | 0.97 |
| ▸ | ADRA1A known ✓ | P35348 | 5/20 | 0.97 |
| ▸ | ADRA1B known ✓ | P35368 | 5/20 | 0.97 |
| ▸ | HTR1D | P28221 | 11/20 | 0.97 |
| ▸ | HTR1B | P28222 | 11/20 | 0.97 |
| ▸ | HTR1A | P08908 | 4/20 | 0.97 |
| ▸ | LMNA | P02545 | 3/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.97 |
| ▸ | TSHR | P16473 | 3/20 | 0.97 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.97 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.97 |
| ▸ | HTR2A | P28223 | 2/20 | 0.97 |
| ▸ | HTR2C | P28335 | 2/20 | 0.97 |
| ▸ | DRD3 | P35462 | 2/20 | 0.97 |
| ▸ | HTR2B | P41595 | 2/20 | 0.97 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxymetazoline SCHEMBL29825106 | 0.99 | HTR1D (1.00) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Oxymetazoline SCHEMBL24301 | 0.99 | HTR1D (1.00) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Oxymetazoline SCHEMBL30495496 | 0.97 | ADRA2A (1.00) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Oxymetazoline SCHEMBL41247 | 0.97 | ADRA2A (1.00) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Oxymetazoline SCHEMBL16115214 | 0.97 | HTR1D (0.97) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Oxymetazoline SCHEMBL16115411 | 0.97 | HTR1D (0.97) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Oxymetazoline SCHEMBL3665660 | 0.97 | HTR1D (0.97) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Oxymetazoline SCHEMBL28206146 | 0.96 | ADRA2A (0.97) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Oxymetazoline SCHEMBL8189197 | 0.94 | HTR1D (0.91) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Oxymetazoline SCHEMBL4630526 | 0.94 | HTR1D (0.91) | HTR1DHTR1BADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2978407-A1 | AQUEOUS SOLUTION COMPOSITION CONTAINING IPRATROPIUM AND OXYMETAZOLINE | Santa Farma Ilaç Sanayi A.S. (TR) | 2016-02-03 | — | — | EP | claimed |
| WO-2014158118-A1 | SUSPENSION COMPOSITION CONTAINING IPRATROPIUM AND OXYMETAZOLINE | SANTA FARMA İLAÇ SANAYİ A.Ş. (TR) | 2014-10-02 | — | — | WO | claimed |
| WO-2014158119-A1 | AQUEOUS SOLUTION COMPOSITION CONTAINING IPRATROPIUM AND OXYMETAZOLINE | SANTA FARMA İLAÇ SANAYİ A.Ş (TR) | 2014-10-02 | — | — | WO | claimed |
| EP-2978407-B1 | AQUEOUS SOLUTION COMPOSITION CONTAINING IPRATROPIUM AND OXYMETAZOLINE | SANTA FARMA ILAC SANAYI A S (TR) | 2020-05-06 | — | — | EP | disclosed |
| US-10391087-B2 | Combination of oxymetazoline and ipratropium in topical nasal application for the treatment of a cough | CORTES BORREGO PABLO (MX) | 2019-08-27 | — | — | US | disclosed |
| US-20180344722-A1 | Combination of Oxymetazoline and Ipratropium in Topical Nasal Application for the Treatment of a Cough | CORTES BORREGO PABLO (MX) | 2018-12-06 | — | — | US | disclosed |
| EP-3384909-A1 | COMBINATION OF OXYMETAZOLINE AND IPRATROPIUM IN TOPICAL NASAL APPLICATION FOR THE TREATMENT OF A COUGH | Cortés Borrego, Pablo (MX) | 2018-10-10 | — | — | EP | disclosed |
| EP-2978407-A1 | AQUEOUS SOLUTION COMPOSITION CONTAINING IPRATROPIUM AND OXYMETAZOLINE | Santa Farma Ilaç Sanayi A.S. (TR) | 2016-02-03 | — | — | EP | disclosed |
| WO-2014158119-A1 | AQUEOUS SOLUTION COMPOSITION CONTAINING IPRATROPIUM AND OXYMETAZOLINE | SANTA FARMA İLAÇ SANAYİ A.Ş (TR) | 2014-10-02 | — | — | WO | disclosed |
| WO-2014158118-A1 | SUSPENSION COMPOSITION CONTAINING IPRATROPIUM AND OXYMETAZOLINE | SANTA FARMA İLAÇ SANAYİ A.Ş. (TR) | 2014-10-02 | — | — | WO | disclosed |