Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2C
The experimentally established mechanism targets of Oxymetazoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 6/20 | 1.00 |
| ▸ | ADRA2B known ✓ | P18089 | 5/20 | 1.00 |
| ▸ | ADRA2C known ✓ | P18825 | 5/20 | 1.00 |
| ▸ | ADRA1D known ✓ | P25100 | 5/20 | 1.00 |
| ▸ | ADRA1A known ✓ | P35348 | 5/20 | 1.00 |
| ▸ | ADRA1B known ✓ | P35368 | 5/20 | 1.00 |
| ▸ | HTR1D | P28221 | 11/20 | 1.00 |
| ▸ | HTR1B | P28222 | 11/20 | 1.00 |
| ▸ | HTR1A | P08908 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 2/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | HTR2A | P28223 | 2/20 | 1.00 |
| ▸ | HTR2C | P28335 | 2/20 | 1.00 |
| ▸ | DRD3 | P35462 | 2/20 | 1.00 |
| ▸ | HTR2B | P41595 | 2/20 | 1.00 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxymetazoline SCHEMBL29825106 | 1.00 | HTR1D (1.00) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Oxymetazoline SCHEMBL30495496 | 0.99 | ADRA2A (1.00) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Oxymetazoline SCHEMBL16114512 | 0.99 | HTR1D (0.97) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Oxymetazoline SCHEMBL41247 | 0.99 | ADRA2A (1.00) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Oxymetazoline SCHEMBL16115214 | 0.99 | HTR1D (0.97) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Oxymetazoline SCHEMBL16115411 | 0.99 | HTR1D (0.97) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Oxymetazoline SCHEMBL3665660 | 0.99 | HTR1D (0.97) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Oxymetazoline SCHEMBL28206146 | 0.97 | ADRA2A (0.97) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Oxymetazoline SCHEMBL8189197 | 0.95 | HTR1D (0.91) | HTR1DHTR1BADRA2AADRA2BADRA2C | |
| Oxymetazoline SCHEMBL4630526 | 0.95 | HTR1D (0.91) | HTR1DHTR1BADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 15657 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4736841-A1 | A MUCOADHESIVE LAYER FOR BUCCAL ADMINISTRATION OF AN ACTIVE PHARMACEUTICAL INGREDIENT | IQ medical GmbH (DE) | 2026-05-06 | — | — | EP | claimed |
| US-12611389-B1 | Compositions and methods to reduce or eliminate nasal biofilms and mucus barriers allowing sodium pyruvate to increase the synthesis of nitric oxide and eliminate nasal infections and their toxins that cause lung, nerve and brain damage | CELLULAR SCIENCES, INC. (US) | 2026-04-28 | — | — | US | claimed |
| US-20260108531-A1 | Methods of Treating Hypogonadism with Transnasal Testosterone Bio-adhesive Gel Formulations in Males with Allergic Rhinitis and Methods for Preventing an Allergic Rhinitis Event | ACERUS BIOPHARMA INC (CA) | 2026-04-23 | — | — | US | claimed |
| US-20260108489-A1 | TOPICAL NASAL PHARMACEUTICAL COMPOSITION FOR THE TREATMENT AND PROPHYLAXIS OF CHRONIC RHINOSINUSITIS (CRS) | VARIZAT EDUARDO ROBERTO (AR) | 2026-04-23 | — | — | US | claimed |
| US-12605345-B2 | Transdermal drug delivery system | BioPhysics Pharma, Inc. (US) | 2026-04-21 | — | — | US | claimed |
| EP-4724079-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION | Stealth BioTherapeutics Inc. (US) | 2026-04-15 | — | — | EP | claimed |
| EP-3578178-B1 | PHARMACEUTICAL COMPOSITION FOR USE IN TREATING ROSACEA COMPRISING OXYMETAZOLINE | EPI HEALTH LLC (US) | 2026-04-08 | — | — | EP | claimed |
| EP-4704839-A2 | IMIDAZOLE CONTAINING COMPOUNDS, DERIVATIVES THEREFORE, AND USES THEREOF | ALPHERABIO LLC (US) | 2026-03-11 | — | — | EP | claimed |
| US-12569451-B2 | Bio-inspired tissue-adhesive hydrogel patch and uses thereof | Cellartgen Inc. (KR) | 2026-03-10 | — | — | US | claimed |
| US-12564521-B2 | Nasal compression device | NASACLIP, INC. (US) | 2026-03-03 | — | — | US | claimed |
| US-4764378-A | MATRICES OF HIGH AND LOW MOLECULAR WEIGHT POLYOXYETHYLENE GLYCOLS | ZETACHRON, INC. (US) | 1988-08-16 | — | — | US | claimed |
| US-4737361-A | Alpha adrenergic amine of substantial alpha2 adrenergic amine activity as an antiperspirant | BRISTOL-MYERS COMPANY (US) | 1988-04-12 | — | — | US | claimed |
| EP-0232877-A2 | Buccal drug dosage form | ZETACHRON, INC. (US) | 1987-08-19 | — | — | EP | claimed |
| EP-0086428-B1 | ANTIDIARRHOEA VETERINARY COMPOSITION, ITS PRODUCTION AND ORAL DOSER CONTAINING IT | BEECHAM GROUP PLC (GB) | 1987-07-29 | — | — | EP | claimed |
| US-4603131-A | Method and composition for treating and preventing irritation of the mucous membranes of the nose | BERNSTEIN, JOEL E. | 1986-07-29 | — | — | US | claimed |
| EP-0046270-B1 | NOVEL DERIVATIVES OF BIO-AFFECTING PHENOLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | INTERx RESEARCH CORPORATION (US) | 1986-05-21 | — | — | EP | claimed |
| EP-0025269-B1 | ANTI-DIARRHOEA VETERINARY COMPOSITION | BEECHAM GROUP PLC (GB) | 1985-11-13 | — | — | EP | claimed |
| EP-0086428-A1 | Antidiarrhoea veterinary composition, its production and oral doser containing it | BEECHAM GROUP PLC (GB) | 1983-08-24 | — | — | EP | claimed |
| EP-0046270-A1 | Novel derivatives of bio-affecting phenolic compounds and pharmaceutical composition containing them | INTERx RESEARCH CORPORATION (US) | 1982-02-24 | — | — | EP | claimed |
| US-4255439-A | Means and method for aiding individuals to stop smoking | COOPER IRVING | 1981-03-10 | — | — | US | claimed |