Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2C
The experimentally established mechanism targets of Oxymetazoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 6/20 | 1.00 |
| ▸ | ADRA2B known ✓ | P18089 | 5/20 | 0.97 |
| ▸ | ADRA2C known ✓ | P18825 | 5/20 | 0.97 |
| ▸ | ADRA1D known ✓ | P25100 | 5/20 | 0.97 |
| ▸ | ADRA1A known ✓ | P35348 | 5/20 | 0.97 |
| ▸ | ADRA1B known ✓ | P35368 | 5/20 | 0.97 |
| ▸ | HTR1A | P08908 | 4/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | BLM | P54132 | 2/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 2/20 | 1.00 |
| ▸ | RAB9A | P51151 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | HTR1D | P28221 | 11/20 | 0.97 |
| ▸ | HTR1B | P28222 | 11/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.97 |
| ▸ | TSHR | P16473 | 3/20 | 0.97 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.97 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.97 |
| ▸ | HTR2A | P28223 | 2/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxymetazoline SCHEMBL30495496 | 1.00 | ADRA2A (1.00) | ADRA2AHTR1ACYP3A4LMNABLM | |
| Oxymetazoline SCHEMBL28206146 | 0.99 | ADRA2A (0.97) | ADRA2AHTR1ACYP3A4LMNABLM | |
| Oxymetazoline SCHEMBL29825106 | 0.99 | HTR1D (1.00) | ADRA2AHTR1ACYP3A4LMNABLM | |
| Oxymetazoline SCHEMBL24301 | 0.99 | HTR1D (1.00) | ADRA2AHTR1ACYP3A4LMNABLM | |
| Oxymetazoline SCHEMBL16115411 | 0.97 | HTR1D (0.97) | ADRA2AHTR1ACYP3A4LMNABLM | |
| Oxymetazoline SCHEMBL3665660 | 0.97 | HTR1D (0.97) | ADRA2AHTR1ACYP3A4LMNABLM | |
| Oxymetazoline SCHEMBL16114512 | 0.97 | HTR1D (0.97) | ADRA2AHTR1ACYP3A4LMNABLM | |
| Oxymetazoline SCHEMBL16115214 | 0.97 | HTR1D (0.97) | ADRA2AHTR1ACYP3A4LMNABLM | |
| Oxymetazoline SCHEMBL8189197 | 0.94 | HTR1D (0.91) | ADRA2AHTR1ACYP3A4LMNABLM | |
| Oxymetazoline SCHEMBL4630526 | 0.94 | HTR1D (0.91) | ADRA2AHTR1ACYP3A4LMNABLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 5084 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122075403-A | Oxymetazoline hydrochloride eye drop composition and preparation method thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122031390-A | Oxymetazoline hydrochloride spray and preparation method thereof | 泰州市第四人民医院 | 2026-05-15 | — | — | CN | claimed |
| US-20260108489-A1 | TOPICAL NASAL PHARMACEUTICAL COMPOSITION FOR THE TREATMENT AND PROPHYLAXIS OF CHRONIC RHINOSINUSITIS (CRS) | VARIZAT EDUARDO ROBERTO (AR) | 2026-04-23 | — | — | US | claimed |
| US-12605363-B2 | Oxymetazoline compositions | RVL PHARMACEUTICALS, INC. (US) | 2026-04-21 | — | — | US | claimed |
| US-20260097016-A1 | STABILIZED OXYMETAZOLINE FORMULATIONS AND THEIR USES | MAYNE PHARMA LLC (US) | 2026-04-09 | — | — | US | claimed |
| US-12564616-B2 | Composition for respiratory diseases | GERSH SOL (US) | 2026-03-03 | — | — | US | claimed |
| US-20260041675-A1 | NASAL COMPOSITION | SATO PHARMACEUTICAL CO., LTD. (JP) | 2026-02-12 | — | — | US | claimed |
| US-12490932-B2 | Ophthalmic drug delivery | EYENOVIA, INC. (US) | 2025-12-09 | — | — | US | claimed |
| US-12350255-B2 | Stabilized oxymetazoline formulations and their uses | MAYNE PHARMA LLC (US) | 2025-07-08 | — | — | US | claimed |
| CN-120131551-A | Rhinitis spray and preparation method thereof | 西安乐口福泰生物医药科技有限公司 | 2025-06-13 | — | — | CN | claimed |
| EP-0666078-A2 | Nasal spray compositions | SCHERING-PLOUGH HEALTHCARE PRODUCTS, INC. (US) | 1995-08-09 | — | — | EP | claimed |
| WO-1995013810-A1 | NASAL SPRAY COMPOSITIONS CONTAINING OXYMETAZOLINE | SCHERING-PLOUGH HEALTHCARE PRODUCTS INCORPORATED (US) | 1995-05-26 | — | — | WO | claimed |
| WO-1994005330-A1 | NASAL SPRAY PRODUCTS | THE PROCTER & GAMBLE COMPANY (US) | 1994-03-17 | — | — | WO | claimed |
| WO-1993024149-A1 | PHARMACEUTICAL POWDER COMPOSITION CONTAINING NON-IONIC CELLULOSE ETHER DERIVATIVE AND A CHITIN-DERIVED POLYMER | THE PROCTER & GAMBLE COMPANY (US) | 1993-12-09 | — | — | WO | claimed |
| EP-0571671-A1 | A Pharmaceutical composition in powder form | THE PROCTER & GAMBLE COMPANY (US) | 1993-12-01 | — | — | EP | claimed |
| US-5114979-A | Pump sprayer or dropper bottle with flavored oxymetazoline | SCHERING CORPORATION (US) | 1992-05-19 | — | — | US | claimed |
| US-4970240-A | OXYMETAZOLINE | SCHERING CORPORATION (US) | 1990-11-13 | — | — | US | claimed |
| US-4603131-A | Method and composition for treating and preventing irritation of the mucous membranes of the nose | BERNSTEIN, JOEL E. | 1986-07-29 | — | — | US | claimed |
| EP-0046270-B1 | NOVEL DERIVATIVES OF BIO-AFFECTING PHENOLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | INTERx RESEARCH CORPORATION (US) | 1986-05-21 | — | — | EP | claimed |
| EP-0093373-A1 | Method and composition for treating and preventing irritation of the mucous membranes of the nose | Bernstein, Joel E. (US) | 1983-11-09 | — | — | EP | claimed |