Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2C
The experimentally established mechanism targets of Oxymetazoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 6/20 | 0.97 |
| ▸ | ADRA2B known ✓ | P18089 | 5/20 | 0.95 |
| ▸ | ADRA2C known ✓ | P18825 | 5/20 | 0.95 |
| ▸ | ADRA1D known ✓ | P25100 | 5/20 | 0.95 |
| ▸ | ADRA1A known ✓ | P35348 | 5/20 | 0.95 |
| ▸ | ADRA1B known ✓ | P35368 | 5/20 | 0.95 |
| ▸ | HTR1A | P08908 | 4/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.97 |
| ▸ | LMNA | P02545 | 3/20 | 0.97 |
| ▸ | BLM | P54132 | 2/20 | 0.97 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.97 |
| ▸ | RAB9A | P51151 | 1/20 | 0.97 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.97 |
| ▸ | HTR1D | P28221 | 11/20 | 0.95 |
| ▸ | HTR1B | P28222 | 11/20 | 0.95 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.95 |
| ▸ | TSHR | P16473 | 3/20 | 0.95 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.95 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.95 |
| ▸ | HTR2A | P28223 | 2/20 | 0.95 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxymetazoline SCHEMBL41247 | 0.99 | ADRA2A (1.00) | ADRA2AHTR1ACYP3A4LMNABLM | |
| Oxymetazoline SCHEMBL30495496 | 0.99 | ADRA2A (1.00) | ADRA2AHTR1ACYP3A4LMNABLM | |
| Oxymetazoline SCHEMBL29825106 | 0.97 | HTR1D (1.00) | ADRA2AHTR1ACYP3A4LMNABLM | |
| Oxymetazoline SCHEMBL24301 | 0.97 | HTR1D (1.00) | ADRA2AHTR1ACYP3A4LMNABLM | |
| Oxymetazoline SCHEMBL16115411 | 0.96 | HTR1D (0.97) | ADRA2AHTR1ACYP3A4LMNABLM | |
| Oxymetazoline SCHEMBL3665660 | 0.96 | HTR1D (0.97) | ADRA2AHTR1ACYP3A4LMNABLM | |
| Oxymetazoline SCHEMBL16114512 | 0.96 | HTR1D (0.97) | ADRA2AHTR1ACYP3A4LMNABLM | |
| Oxymetazoline SCHEMBL16115214 | 0.96 | HTR1D (0.97) | ADRA2AHTR1ACYP3A4LMNABLM | |
| Oxymetazoline SCHEMBL8189197 | 0.93 | HTR1D (0.91) | ADRA2AHTR1ACYP3A4LMNABLM | |
| Oxymetazoline SCHEMBL4630526 | 0.93 | HTR1D (0.91) | ADRA2AHTR1ACYP3A4LMNABLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107810197-A | METHODS OF IDENTIFYING BACTERIA COMPRISING BINDING POLYPEPTIDES | 豪夫迈·罗氏有限公司 | 2018-03-16 | — | — | CN | disclosed |