Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL453514 | 0.87 | PARP1 (0.72) | PARP1KDM4EHPGDRXFP1 | |
| SCHEMBL9218238 | 0.85 | PARP1 (0.70) | PARP1KDM4EHPGDRXFP1 | |
| Hydrochloric Acid SCHEMBL22165594 | 0.85 | PARP1 (0.70) | PARP1KDM4EHPGDRXFP1 | |
| SCHEMBL28284556 | 0.85 | PARP1 (0.70) | PARP1KDM4EHPGDRXFP1 | |
| Hydrochloric Acid SCHEMBL2129546 | 0.85 | PARP1 (0.70) | PARP1KDM4EHPGDRXFP1 | |
| Acetic Acid SCHEMBL7575146 | 0.82 | PARP1 (0.66) | PARP1KDM4EHPGDRXFP1 | |
| SCHEMBL16115021 | 0.82 | PARP1 (0.55) | PARP1RXFP1PRMT5 | |
| Trifluoroacetic Acid SCHEMBL20482044 | 0.81 | PARP1 (0.60) | PARP1KDM4EHPGDRXFP1 | |
| SCHEMBL28267894 | 0.79 | PARP1 (0.61) | PARP1KDM4EHPGDRXFP1PRMT5 | |
| Tromethamine SCHEMBL16115022 | 0.78 | KEAP1 (0.39) | PARP1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014158467-A1 | COMBINATION | GLAXOSMITHKLINE LLC (US) | 2014-10-02 | — | — | WO | disclosed |