Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | GAPDH | P04406 | 1/20 | 0.46 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.46 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.46 |
| ▸ | CD44 | P16070 | 1/20 | 0.46 |
| ▸ | MSN | P26038 | 1/20 | 0.46 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.46 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | PNMT | P11086 | 9/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10293160 | 1.00 | GAA (0.54) | GAAMAPTGAPDHHSPA1AHSPA8 | |
| SCHEMBL29697818 | 1.00 | GAA (0.54) | GAAMAPTGAPDHHSPA1AHSPA8 | |
| SCHEMBL16116108 | 0.90 | GAA (0.55) | GAAMAPTGAPDHHSPA1AHSPA8 | |
| SCHEMBL30213424 | 0.90 | GAA (0.55) | GAAMAPTGAPDHHSPA1AHSPA8 | |
| SCHEMBL4537304 | 0.90 | GAA (0.55) | GAAMAPTGAPDHHSPA1AHSPA8 | |
| SCHEMBL13362053 | 0.87 | SIRT2 (0.43) | GAAMAPTGAPDHHSPA1AHSPA8 | |
| SCHEMBL28788156 | 0.83 | MAPT (0.46) | MAPTSIRT2PNMTADRA2AADRA2B | |
| SCHEMBL20939589 | 0.83 | PNMT (0.43) | GAASIRT2PNMTADRA2AADRA2B | |
| SCHEMBL26597092 | 0.83 | MAPT (0.46) | MAPTSIRT2PNMTADRA2AADRA2B | |
| SCHEMBL13362052 | 0.82 | SIRT2 (0.47) | GAPDHHSPA1AHSPA8CD44MSN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10329324-B2 | Indoline compounds as granzyme B inhibitors | viDA Therapeutics (CA) | 2019-06-25 | — | — | US | disclosed |
| US-20180057528-A1 | INDOLINE COMPOUNDS AS GRANZYME B INHIBITORS | VIDA THERAPEUTICS INC. (CA) | 2018-03-01 | — | — | US | disclosed |
| US-9605021-B2 | Indoline compounds as granzyme B inhibitors | VIDA THERAPEUTICS INC. (CA) | 2017-03-28 | — | — | US | disclosed |
| US-20160083422-A1 | INDOLINE COMPOUNDS AS GRANZYME B INHIBITORS | VIDA THERAPEUTICS INC. (CA) | 2016-03-24 | — | — | US | disclosed |
| WO-2014153667-A1 | COSMETIC USES AND METHODS FOR INDOLINE GRANZYME B INHIBITOR COMPOSITIONS | VIDA THERAPEUTICS, INC. (CA) | 2014-10-02 | — | — | WO | disclosed |
| WO-2014153666-A1 | INDOLINE COMPOUNDS AS GRANZYME B INHIBITORS | VIDA THERAPEUTICS, INC. (CA) | 2014-10-02 | — | — | WO | disclosed |
| CN-1558759-A | Viral polymerase inhibitors | ���ָ����Ӣ��ķ���ô�����˾ | 2004-12-29 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180057528-A1 | INDOLINE COMPOUNDS AS GRANZYME B INHIBITORS | GZMB, PRF1, CTSB | GAA 141/4885MAPT 3993/4885GAPDH 2007/4885 |
| US-10329324-B2 | Indoline compounds as granzyme B inhibitors | GZMB, PRF1, CTSB | GAA 141/4885MAPT 3993/4885GAPDH 2007/4885 |
| US-20160083422-A1 | INDOLINE COMPOUNDS AS GRANZYME B INHIBITORS | GZMB, PRF1, CTSB | GAA 141/4885MAPT 3993/4885GAPDH 2007/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.