Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | MLNR | O43193 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16118651 | 0.89 | TSHR (0.42) | LMNATSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16099597 | 0.88 | ALDH1A1 (0.58) | LMNATSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16118647 | 0.88 | GAA (0.43) | LMNATSHRMEN1KMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL29391379 | 0.87 | ALDH1A1 (0.57) | LMNATSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16118646 | 0.87 | PKM (0.50) | LMNATSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16118645 | 0.86 | MLNR (0.42) | LMNATSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16118649 | 0.85 | NPC1 (0.44) | LMNATSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16118644 | 0.83 | MLNR (0.42) | LMNATSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16118659 | 0.83 | KMT2A (0.51) | LMNATSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16118654 | 0.83 | KMT2A (0.51) | LMNATSHRMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9796674-B2 | Benzyl urea derivatives for activating TGF-beta signaling | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS | 2017-10-24 | — | — | US | disclosed |
| US-9796674-B2 | Benzyl urea derivatives for activating TGF-beta signaling | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS | 2017-10-24 | — | — | US | disclosed |
| US-20160039756-A1 | BENZYL UREA DERIVATIVES FOR ACTIVATING TGF-BETA SIGNALING | The Board of Trustees of the Leladn Stanford Junior University (US) | 2016-02-11 | — | — | US | disclosed |
| US-20160039756-A1 | BENZYL UREA DERIVATIVES FOR ACTIVATING TGF-BETA SIGNALING | The Board of Trustees of the Leladn Stanford Junior University (US) | 2016-02-11 | — | — | US | disclosed |
| WO-2014152869-A2 | BENZYL UREA DERIVATIVES FOR ACTIVATING TGF-BETA SIGNALING | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2014-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160039756-A1 | BENZYL UREA DERIVATIVES FOR ACTIVATING TGF-BETA SIGNALING | TGFBR1, TGFB1, TGFBR2 | LMNA 1092/4885TSHR 3384/4885MEN1 4373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.