SCHEMBL1611980

SCHEMBL1611980

C=Cc1ccc(CC(C)(C)C)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRA P10827 1/20 0.53
THRB P10828 1/20 0.53
ESR1 P03372 3/20 0.52
ALDH1A1 P00352 3/20 0.50
TSHR P16473 1/20 0.39
HDAC8 Q9BY41 1/20 0.38
CHRNA4 P43681 2/20 0.34
SLC6A2 P23975 2/20 0.34
TDP1 Q9NUW8 2/20 0.34
HTR2A P28223 1/20 0.34
SLC6A4 P31645 1/20 0.34
HRH1 P35367 1/20 0.34
HTR2B P41595 1/20 0.34
SLC6A3 Q01959 1/20 0.34
CHRNB2 P17787 1/20 0.34
CHRNB4 P30926 1/20 0.34
CHRNA3 P32297 1/20 0.34
CHRNA7 P36544 1/20 0.34
ESR2 Q92731 2/20 0.33
CYP3A4 P08684 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21709825 0.84 NPC1 (0.44) THRATHRBESR1CHRNA4TDP1
SCHEMBL21330385 0.83 ALDH1A1 (0.46) THRATHRBESR1ALDH1A1TSHR
SCHEMBL27520515 0.83 SLC6A2 (0.55) THRATHRBESR1ALDH1A1TSHR
SCHEMBL10597489 0.83 ALDH1A1 (0.46) THRATHRBESR1ALDH1A1TSHR
SCHEMBL5199704 0.81 ALDH1A1 (0.44) THRATHRBESR1ALDH1A1TSHR
SCHEMBL6289217 0.81 ALDH1A1 (0.44) THRATHRBESR1ALDH1A1TSHR
SCHEMBL6685103 0.80 ESR1 (0.74) THRATHRBESR1ALDH1A1TSHR
SCHEMBL14268192 0.79 ALDH1A1 (0.42) THRATHRBESR1ALDH1A1TSHR
SCHEMBL21901752 0.79 ALDH1A1 (0.42) THRATHRBESR1ALDH1A1TSHR
SCHEMBL1612743 0.79 ESR1 (0.54) THRATHRBESR1CHRNA4SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12577389-B2 Thermoplastic moulding materials with improved property profile CLARIANT INTERNATIONAL LTD (CH) 2026-03-17 US disclosed
US-12404434-B2 Absorbent articles comprising a SBC based hotmelt adhesive THE PROCTER & GAMBEL COMPANY (US) 2025-09-02 US disclosed
EP-3854365-B1 ABSORBENT ARTICLES COMPRISING A SBC BASED HOTMELT ADHESIVE PROCTER & GAMBLE (US) 2023-07-19 EP disclosed
US-20230084553-A1 THERMOPLASTIC MOULDING MATERIALS WITH IMPROVED PROPERTY PROFILE CLARIANT INTERNATIONAL LTD (CH) 2023-03-16 US disclosed
EP-4097188-A1 THERMOPLASTIC MOULDING MATERIALS WITH IMPROVED PROPERTY PROFILE Clariant International Ltd (CH) 2022-12-07 EP disclosed
CN-115003772-A Thermoplastic molding materials with improved performance characteristics 科莱恩国际有限公司 2022-09-02 CN disclosed
WO-2021151838-A1 THERMOPLASTIC MOULDING MATERIALS WITH IMPROVED PROPERTY PROFILE CLARIANT INTERNATIONAL LTD (CH) 2021-08-05 WO disclosed
US-20210230464-A1 Absorbent articles comprising a SBC based hotmelt adhesive THE PROCTER & GAMBLE COMPANY 2021-07-29 US disclosed
EP-3854365-A1 ABSORBENT ARTICLES COMPRISING A SBC BASED HOTMELT ADHESIVE The Procter & Gamble Company (US) 2021-07-28 EP disclosed
US-20110087034-A1 Organic Semiconductor Material SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2011-04-14 US disclosed
EP-2248818-A1 ORGANIC SEMICONDUCTOR MATERIAL Sumitomo Chemical Company, Limited (JP) 2010-11-10 EP disclosed
US-7439305-B2 Hot-melt adhesive HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2008-10-21 US disclosed
US-20070282072-A1 Hot-Melt Adhesive HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2007-12-06 US disclosed
US-6165455-A Personal care compositions containing thermoplastic elastomeric graft copolymers THE PROCTER & GAMBLE COMPANY (US) 2000-12-26 US disclosed
EP-0768862-A1 PERSONAL CARE COMPOSITIONS CONTAINING THERMOPLASTIC ELASTOMERIC GRAFT COPOLYMERS THE PROCTER & GAMBLE COMPANY (US) 1997-04-23 EP disclosed
WO-1996000562-A1 PERSONAL CARE COMPOSITIONS CONTAINING THERMOPLASTIC ELASTOMERIC GRAFT COPOLYMERS THE PROCTER & GAMBLE COMPANY (US) 1996-01-11 WO disclosed
US-4909896-A Irradiating with charged particles; etching HOYA CORPORATION (JP) 1990-03-20 US disclosed
EP-0331090-A2 Process for producing contact lens HOYA CORPORATION (JP) 1989-09-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12577389-B2 Thermoplastic moulding materials with improved property profile POLM, ITGAM, MSH2 THRA 3185/4885THRB 3004/4885ESR1 3235/4885
US-20110087034-A1 Organic Semiconductor Material OR10J3, TST, OR51E2 THRA 2721/4885THRB 2154/4885ESR1 1107/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.