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SCHEMBL16125366

SCHEMBL16125366

COc1ccc(C(F)(F)F)cc1-c1n[nH]cc1CN(C)CCN

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ PRMT6 Q96LA8 3/20 0.48
▸ PRMT8 Q9NR22 3/20 0.48
▸ PRMT3 O60678 2/20 0.48
▸ CARM1 Q86X55 2/20 0.48
▸ PRMT1 Q99873 2/20 0.48
▸ KDM1A O60341 1/20 0.38
▸ DHFR P00374 2/20 0.37
▸ CETP P11597 5/20 0.37
▸ KDM4E B2RXH2 1/20 0.36
▸ ALDH1A1 P00352 1/20 0.36
▸ PTGDR2 Q9Y5Y4 4/20 0.36
▸ SCN9A Q15858 2/20 0.35
▸ TBXA2R P21731 1/20 0.34
▸ PTGDR Q13258 1/20 0.34
▸ ALK Q9UM73 1/20 0.33
▸ HTR2A P28223 1/20 0.33
▸ HTR2C P28335 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16125380 0.90 CETP (0.38) PRMT6PRMT8PRMT3CARM1PRMT1
SCHEMBL16121394 0.88 PRMT6 (0.51) PRMT6PRMT8PRMT3CARM1PRMT1
SCHEMBL16201176 0.86 PRMT6 (0.51) PRMT6PRMT8PRMT3CARM1PRMT1
SCHEMBL16201236 0.86 PRMT6 (0.51) PRMT6PRMT8PRMT3CARM1PRMT1
SCHEMBL16201249 0.86 ALDH1A1 (0.48) PRMT6PRMT8PRMT3CARM1PRMT1
SCHEMBL16201225 0.84 CARM1 (0.49) PRMT6PRMT8PRMT3CARM1PRMT1
SCHEMBL16201248 0.84 CARM1 (0.41) CARM1PRMT1KDM4EALDH1A1
SCHEMBL16201183 0.82 PRMT1 (0.50) PRMT6PRMT8PRMT3CARM1PRMT1
SCHEMBL16201200 0.81 CHRM2 (0.44) PRMT6PRMT8CARM1PRMT1ALDH1A1
SCHEMBL16124176 0.80 PRMT6 (0.69) PRMT6PRMT8PRMT3CARM1PRMT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190022064-A1 PRMT1 Inhibitors and Uses Thereof Epizyme, Inc. 2019-01-24 — — US disclosed
US-10039748-B2 PRMT1 inhibitors and uses thereof Epizyme, Inc. (US) 2018-08-07 — — US disclosed
US-10039748-B2 PRMT1 inhibitors and uses thereof Epizyme, Inc. (US) 2018-08-07 — — US disclosed
US-20170182005-A1 PRMT1 INHIBITORS AND USES THEREOF Epizyme, Inc. (US) 2017-06-29 — — US disclosed
US-20170182005-A1 PRMT1 INHIBITORS AND USES THEREOF Epizyme, Inc. (US) 2017-06-29 — — US disclosed
US-9447079-B2 PRMT1 inhibitors and uses thereof Epizyme, Inc. (US) 2016-09-20 — — US disclosed
US-9447079-B2 PRMT1 inhibitors and uses thereof Epizyme, Inc. (US) 2016-09-20 — — US disclosed
US-20140288129-A1 PRMT1 INHIBITORS AND USES THEREOF Epizyme, Inc. (US) 2014-09-25 — — US disclosed
US-20140288129-A1 PRMT1 INHIBITORS AND USES THEREOF Epizyme, Inc. (US) 2014-09-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190022064-A1 PRMT1 Inhibitors and Uses Thereof PRMT1, PRMT3, PRMT5 PRMT6 4/4885PRMT8 7/4885PRMT3 2/4885
US-10039748-B2 PRMT1 inhibitors and uses thereof PRMT1, PRMT3, PRMT5 PRMT6 4/4885PRMT8 7/4885PRMT3 2/4885
US-20170182005-A1 PRMT1 INHIBITORS AND USES THEREOF PRMT1, PRMT3, PRMT5 PRMT6 4/4885PRMT8 7/4885PRMT3 2/4885
US-20140288129-A1 PRMT1 INHIBITORS AND USES THEREOF PRMT1, PRMT3, PRMT5 PRMT6 4/4885PRMT8 7/4885PRMT3 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.