Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.53 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.47 |
| ▸ | HTR6 | P50406 | 9/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | UBE2N | P61088 | 1/20 | 0.45 |
| ▸ | KLK7 | P49862 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20424529 | 0.91 | AKR1C3 (0.64) | LMNASMN1; SMN2AKR1C3AKR1C1ALOX5 | |
| SCHEMBL946621 | 0.89 | LMNA (0.71) | LMNASMN1; SMN2AKR1C3AKR1C1HTR6 | |
| SCHEMBL23219219 | 0.87 | MEN1 (0.58) | LMNASMN1; SMN2AKR1C3AKR1C1ALOX5 | |
| SCHEMBL31748353 | 0.87 | ALOX5 (0.50) | LMNASMN1; SMN2AKR1C3AKR1C1ALOX5 | |
| SCHEMBL19839201 | 0.86 | AKR1C3 (0.49) | LMNASMN1; SMN2AKR1C3AKR1C1ALOX5 | |
| SCHEMBL12748673 | 0.84 | AKR1C3 (0.68) | LMNASMN1; SMN2AKR1C3AKR1C1ALOX5 | |
| SCHEMBL31571431 | 0.83 | HTR6 (0.55) | AKR1C3AKR1C1HTR6CYP3A4CYP2D6 | |
| SCHEMBL23589255 | 0.83 | HTR6 (0.55) | AKR1C3AKR1C1HTR6CYP3A4CYP2D6 | |
| SCHEMBL28504095 | 0.82 | HTR6 (0.49) | AKR1C3AKR1C1ALOX5HTR6CYP3A4 | |
| SCHEMBL16205467 | 0.82 | LMNA (0.49) | LMNASMN1; SMN2AKR1C3AKR1C1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11672780-B2 | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-06-13 | — | — | US | disclosed |
| US-20180000790-A1 | [1,2,4]TRIAZOLO[1,5-a]PYRIDINYL SUBSTITUTED INDOLE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY | 2018-01-04 | — | — | US | disclosed |
| EP-2315751-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | Amgen Inc. (US) | 2011-05-04 | — | — | EP | disclosed |
| US-20110086834-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2011-04-14 | — | — | US | disclosed |
| US-20110086834-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2011-04-14 | — | — | US | disclosed |
| US-20110086834-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2011-04-14 | — | — | US | disclosed |
| WO-2009158011-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2009-12-30 | — | — | WO | disclosed |
| WO-2009158011-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2009-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11672780-B2 | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds | TLR7, TLR1, TLR5 | LMNA 2619/4885SMN1; SMN2 4357/4885AKR1C3 1215/4885 |
| US-20180000790-A1 | [1,2,4]TRIAZOLO[1,5-a]PYRIDINYL SUBSTITUTED INDOLE COMPOUNDS | TLR7, TLR1, TLR5 | LMNA 2619/4885SMN1; SMN2 4357/4885AKR1C3 1215/4885 |
| US-20110086834-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | NFKBIA, MAP3K1, MAP3K2 | LMNA 2017/4885SMN1; SMN2 2966/4885AKR1C3 318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.