Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 6/20 | 0.45 |
| ▸ | ATXN2 | Q99700 | 2/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.44 |
| ▸ | TACR1 | P25103 | 3/20 | 0.42 |
| ▸ | STS | P08842 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CETP | P11597 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16129897 | 0.94 | TACR1 (0.47) | ENPP2ATXN2GPR119TACR1STS | |
| SCHEMBL16129754 | 0.90 | ENPP2 (0.39) | ENPP2ATXN2GPR119TACR1STS | |
| SCHEMBL16129772 | 0.90 | ATXN2 (0.43) | ENPP2ATXN2GPR119TACR1STS | |
| SCHEMBL16129902 | 0.89 | ENPP2 (0.46) | ENPP2ATXN2TACR1KCNH2 | |
| SCHEMBL16129744 | 0.88 | ENPP2 (0.43) | ENPP2ATXN2KCNH2 | |
| SCHEMBL16129736 | 0.87 | ENPP2 (0.43) | ENPP2ATXN2TACR1POLBMEN1 | |
| SCHEMBL16100530 | 0.87 | ENPP2 (0.46) | ENPP2ATXN2TACR1MEN1KMT2A | |
| SCHEMBL16129884 | 0.86 | ENPP2 (0.43) | ENPP2ATXN2KCNH2 | |
| SCHEMBL16101985 | 0.85 | ENPP2 (0.43) | ENPP2ATXN2TACR1POLBMEN1 | |
| SCHEMBL16129893 | 0.85 | TACR1 (0.39) | ENPP2ATXN2TACR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014152725-A1 | S1P AND/OR ATX MODULATING AGENTS | BIOGEN IDEC MA INC. (US) | 2014-09-25 | — | — | WO | disclosed |