Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.42 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16130358 | 0.94 | ALDH1A1 (0.39) | ALDH1A1LMNALPAR3LPAR2CYP3A4 | |
| SCHEMBL16130385 | 0.86 | TSHR (0.41) | ALDH1A1LMNACYP3A4MAPTUSP2 | |
| SCHEMBL27982815 | 0.85 | ALDH1A1 (0.44) | ALDH1A1LMNALPAR3LPAR2CYP3A4 | |
| SCHEMBL4202943 | 0.83 | ALDH1A1 (0.47) | ALDH1A1LMNALPAR3LPAR2CYP3A4 | |
| SCHEMBL27722089 | 0.83 | ALDH1A1 (0.47) | ALDH1A1LMNALPAR3LPAR2CYP3A4 | |
| SCHEMBL8635690 | 0.83 | ALDH1A1 (0.41) | ALDH1A1LMNALPAR3LPAR2CYP3A4 | |
| SCHEMBL15623821 | 0.82 | NAAA (0.41) | ALDH1A1CYP3A4TSHR | |
| SCHEMBL28439905 | 0.82 | NAAA (0.41) | ALDH1A1CYP3A4TSHR | |
| SCHEMBL15802651 | 0.82 | NAAA (0.41) | ALDH1A1CYP3A4TSHR | |
| SCHEMBL28268034 | 0.82 | NAAA (0.41) | ALDH1A1CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8846638-B2 | Macrocyclic nucleoside phosphoramidate derivatives | ENANTA PHARMACEUTICALS, INC. (US) | 2014-09-30 | — | — | US | disclosed |
| US-8846638-B2 | Macrocyclic nucleoside phosphoramidate derivatives | ENANTA PHARMACEUTICALS, INC. (US) | 2014-09-30 | — | — | US | disclosed |