Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.52 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 4/20 | 0.51 |
| ▸ | MET | P08581 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 4/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | APAF1 | O14727 | 1/20 | 0.48 |
| ▸ | HK1 | P19367 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12004153 | 1.00 | MAPT (0.55) | MAPTALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL1613586 | 1.00 | MAPT (0.55) | MAPTALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL4584118 | 0.91 | MAPT (0.55) | MAPTALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL5716830 | 0.84 | MAOB (0.65) | MAPTALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL7065418 | 0.84 | MAOB (0.65) | MAPTALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL8909177 | 0.81 | MET (0.48) | MAPTALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL8909174 | 0.81 | MET (0.48) | MAPTALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL5443427 | 0.80 | MET (0.45) | MAPTALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL5443416 | 0.80 | MET (0.45) | MAPTALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL20739004 | 0.80 | MAPT (0.55) | MAPTALDH1A1KDM4ECYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8436013-B2 | Compounds and methods for treatment of alpha-1 antitrypsin deficiency | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2013-05-07 | — | — | US | claimed |
| US-20100076018-A1 | Compounds and Methods for Treatment of Alpha-1 Antitrypsin Deficiency | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2010-03-25 | — | — | US | claimed |
| EP-2114141-A2 | COMPOUNDS AND METHODS FOR TREATMENT OF ALPHA-1 ANTITRYPSIN DEFICIENCY | University of Florida (US) | 2009-11-11 | — | — | EP | claimed |
| WO-2008143633-A2 | COMPOUNDS AND METHODS FOR TREATMENT OF ALPHA-1 ANTITRYPSIN DEFICIENCY | UNIVERSITY OF FLORIDA (US) | 2008-11-27 | — | — | WO | claimed |
| EP-0954596-B1 | ENHANCED PRODUCTION OF TAXANES BY CELL CULTURES OF TAXUS SPECIES | PHYTON INC (US) | 2006-01-04 | — | — | EP | claimed |
| EP-1538214-A1 | Enhanced production of taxanes by cell cultures of taxus species | PHYTON, INC. (US) | 2005-06-08 | — | — | EP | claimed |
| EP-0954596-A1 | ENHANCED PRODUCTION OF TAXANES BY CELL CULTURES OF $i(TAXUS) SPECIES | PHYTON, INC. (US) | 1999-11-10 | — | — | EP | claimed |
| WO-1997044476-A1 | ENHANCED PRODUCTION OF TAXANES BY CELL CULTURES OF TAXUS SPECIES | PHYTON, INC. (US) | 1997-11-27 | — | — | WO | claimed |
| EP-2565245-B1 | Moisture-proof material | NITTO DENKO CORP (JP) | 2018-07-25 | — | — | EP | disclosed |
| EP-2661431-B1 | HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK | BIOENERGENIX (US) | 2018-07-11 | — | — | EP | disclosed |
| US-9546303-B2 | Moisture-proof material | NITTO DENKO CORPORATION (JP) | 2017-01-17 | — | — | US | disclosed |
| US-9073902-B2 | Substituted quinoxaline carboxylic acid compounds for the inhibition of PASK | BIOENERGENIX, LLC (US) | 2015-07-07 | — | — | US | disclosed |
| US-20130337261-A1 | MOISTURE-PROOF MATERIAL | NITTO DENKO CORPORATION (JP) | 2013-12-19 | — | — | US | disclosed |
| EP-2666836-A2 | Moisture-proof material | Nitto Denko Corporation (JP) | 2013-11-27 | — | — | EP | disclosed |
| EP-0700396-A1 | PIPERIDINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1996-03-13 | — | — | EP | disclosed |
| US-5478845-A | Inhibit dopamine or 5-hydroxytryptamine receptor binding | NOVO NORDISK A/S (DK) | 1995-12-26 | — | — | US | disclosed |
| WO-1994027992-A1 | PIPERIDINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1994-12-08 | — | — | WO | disclosed |
| WO-1994027994-A1 | PIPERIDINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1994-12-08 | — | — | WO | disclosed |
| US-4058607-A | DIHALOVINYL DIALKYL PHOSPHATE, 1,3-BENZODIOXOLES | AIRWICK INDUSTRIES, INC. (US) | 1977-11-15 | — | — | US | disclosed |
| US-3962415-A | Insecticide evaporator comprising DDVP with synergized benzodioxole compound as stabilizer | AIRWICK INDUSTRIES, INC. (US) | 1976-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100076018-A1 | Compounds and Methods for Treatment of Alpha-1 Antitrypsin Deficiency | SERPINA2, SERPINB1, SERPINC1 | MAPT 2391/4885ALDH1A1 202/4885KDM4E 4276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.