Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GCK | P35557 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16137853 | 0.89 | HSD17B10 (0.47) | MEN1KMT2AHSD17B10MAPTPOLB | |
| SCHEMBL16112291 | 0.88 | NOS2 (0.40) | MEN1KMT2AMAPTRECQLALDH1A1 | |
| SCHEMBL17504045 | 0.88 | NPC1 (0.43) | KMT2AMAPTCYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL17504017 | 0.87 | PTGER3 (0.39) | MAPTPOLBRECQLALDH1A1MCL1 | |
| SCHEMBL16144684 | 0.87 | HSD17B10 (0.54) | MEN1KMT2AHSD17B10MAPTPOLB | |
| SCHEMBL17503998 | 0.83 | NPC1 (0.41) | MEN1KMT2AMAPTCYP2C9CYP2C19 | |
| SCHEMBL16753139 | 0.82 | MAPK14 (0.50) | KMT2ARAB9ANPC1 | |
| SCHEMBL16111535 | 0.77 | F9 (0.68) | F9 | |
| SCHEMBL16753863 | 0.77 | F9 (0.56) | F9 | |
| SCHEMBL16144668 | 0.75 | ALDH1A1 (0.40) | MEN1KMT2AHSD17B10MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3138839-B1 | PYRIDONE OR PYRIMIDONE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | SICHUAN HAISCO PHARMACEUTICAL CO LTD (CN) | 2020-10-28 | — | — | EP | disclosed |
| CN-105829298-B | A kind of pyridone or pyrimidone derivatives, and its preparation method and application | 四川海思科制药有限公司 | 2019-02-01 | — | — | CN | disclosed |
| US-10174020-B2 | Pyridone or pyrimidone derivative, preparation method therefor and application thereof | SICHUAN HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2019-01-08 | — | — | US | disclosed |
| US-10174020-B2 | Pyridone or pyrimidone derivative, preparation method therefor and application thereof | SICHUAN HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2019-01-08 | — | — | US | disclosed |
| US-9809545-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-11-07 | — | — | US | disclosed |
| US-9809545-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-11-07 | — | — | US | disclosed |
| US-9809545-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-11-07 | — | — | US | disclosed |
| EP-2978425-B1 | FACTOR XIA INHIBITORS | MERCK SHARP & DOHME (US) | 2017-09-27 | — | — | EP | disclosed |
| EP-3138839-A1 | PYRIDONE OR PYRIMIDONE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Sichuan Haisco Pharmaceutical Co., Ltd. (CN) | 2017-03-08 | — | — | EP | disclosed |
| EP-3138839-A1 | PYRIDONE OR PYRIMIDONE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Sichuan Haisco Pharmaceutical Co., Ltd. (CN) | 2017-03-08 | — | — | EP | disclosed |
| US-20170029423-A1 | PYRIDONE OR PYRIMIDONE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | SICHUAN HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2017-02-02 | — | — | US | disclosed |
| US-20170029423-A1 | PYRIDONE OR PYRIMIDONE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | SICHUAN HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2017-02-02 | — | — | US | disclosed |
| US-20170029423-A1 | PYRIDONE OR PYRIMIDONE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | SICHUAN HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2017-02-02 | — | — | US | disclosed |
| CN-105829298-A | Pyridone or pyrimidone derivative, preparation method therefor and application thereof | 四川海思科制药有限公司 | 2016-08-03 | — | — | CN | disclosed |
| US-20160046581-A1 | Factor XIa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-02-18 | — | — | US | disclosed |
| US-20160046581-A1 | Factor XIa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-02-18 | — | — | US | disclosed |
| US-20160046581-A1 | Factor XIa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-02-18 | — | — | US | disclosed |
| WO-2015120777-A1 | PYRIDONE OR PYRIMIDONE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 四川海思科制药有限公司 | 2015-08-20 | — | — | WO | disclosed |
| WO-2015120777-A1 | PYRIDONE OR PYRIMIDONE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 四川海思科制药有限公司 | 2015-08-20 | — | — | WO | disclosed |
| WO-2014160592-A2 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160046581-A1 | Factor XIa Inhibitors | F11, F12, TFPI | MEN1 1105/4885KMT2A 3115/4885HSD17B10 1681/4885 |
| US-10174020-B2 | Pyridone or pyrimidone derivative, preparation method therefor and application thereof | TYMP, DHFR, TYMS | MEN1 882/4885KMT2A 3474/4885HSD17B10 1558/4885 |
| US-20170029423-A1 | PYRIDONE OR PYRIMIDONE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | TYMP, DHFR, TYMS | MEN1 882/4885KMT2A 3474/4885HSD17B10 1558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.