Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 9/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1615750 | 1.00 | FGFR1 (0.44) | FGFR1HPGDALDH1A1TP53GABRA1 | |
| SCHEMBL1616875 | 0.91 | FGFR1 (0.42) | FGFR1HPGDALDH1A1KDR | |
| SCHEMBL1617267 | 0.91 | FGFR1 (0.42) | FGFR1HPGDALDH1A1KDR | |
| SCHEMBL1616085 | 0.89 | GABRA1 (0.44) | FGFR1HPGDALDH1A1TP53GABRA1 | |
| SCHEMBL1616914 | 0.89 | GABRA1 (0.44) | FGFR1HPGDALDH1A1TP53GABRA1 | |
| SCHEMBL1762205 | 0.88 | FGFR1 (0.44) | FGFR1HPGDALDH1A1TP53GABRA1 | |
| SCHEMBL1761658 | 0.88 | FGFR1 (0.44) | FGFR1HPGDALDH1A1TP53GABRA1 | |
| SCHEMBL1616721 | 0.88 | FGFR1 (0.38) | FGFR1HPGDALDH1A1TP53GABRA1 | |
| SCHEMBL1617023 | 0.88 | FGFR1 (0.38) | FGFR1HPGDALDH1A1TP53GABRA1 | |
| SCHEMBL1616872 | 0.87 | KDR (0.52) | FGFR1HPGDGABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996556-B1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH AS (DK) | 2009-11-18 | — | — | EP | claimed |
| EP-1996556-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NeuroSearch A/S (DK) | 2008-12-03 | — | — | EP | claimed |
| WO-2007065864-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2007-06-14 | — | — | WO | claimed |
| US-7923464-B2 | Benzimidazole derivatives and their use for modulating the GABAA receptor complex | NEUROSEARCH A/S (DK) | 2011-04-12 | — | — | US | disclosed |
| EP-1996556-B1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH AS (DK) | 2009-11-18 | — | — | EP | disclosed |
| US-20090048321-A1 | Benzimidazole Derivatives and Their Use for Modulating the GABA-Alpha Receptor Complex | ANIONA APS (DK) | 2009-02-19 | — | — | US | disclosed |
| EP-1996556-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NeuroSearch A/S (DK) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007065864-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2007-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048321-A1 | Benzimidazole Derivatives and Their Use for Modulating the GABA-Alpha Receptor Complex | GABRB1, GABRB2, GABRB3 | FGFR1 3792/4885HPGD 2480/4885ALDH1A1 514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.