Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.37 |
| ▸ | CBX7 | O95931 | 1/20 | 0.37 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.37 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.36 |
| ▸ | PDE9A | O76083 | 4/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16175826 | 0.89 | NPBWR1 (0.44) | ADAMTS5CBX7CDYLNPBWR1AKR1B1 | |
| SCHEMBL16175837 | 0.87 | NPBWR1 (0.44) | ADAMTS5CBX7CDYLNPBWR1MEN1 | |
| SCHEMBL16166413 | 0.85 | ADAMTS5 (0.38) | ADAMTS5CBX7CDYLNPBWR1AKR1B1 | |
| SCHEMBL16166339 | 0.85 | IP6K1 (0.42) | PDE9AAKR1B1KDM4E | |
| SCHEMBL16166482 | 0.85 | IP6K1 (0.42) | PDE9AAKR1B1KDM4E | |
| SCHEMBL16166116 | 0.83 | AKR1B1 (0.38) | AKR1B1 | |
| SCHEMBL16166247 | 0.82 | AKR1B1 (0.40) | CBX7CDYLAKR1B1MEN1KMT2A | |
| SCHEMBL16166401 | 0.82 | AKR1B1 (0.40) | CBX7CDYLAKR1B1MEN1KMT2A | |
| SCHEMBL16166409 | 0.79 | AKR1B1 (0.36) | ADAMTS5CBX7CDYLNPBWR1AKR1B1 | |
| SCHEMBL16166565 | 0.79 | HTR2C (0.38) | AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014167528-A1 | SPIROPYRAZOLOPYRIDINE DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF VIRAL INFECTIONS | NOVARTIS AG (CH) | 2014-10-16 | — | — | WO | disclosed |
| WO-2014167528-A1 | SPIROPYRAZOLOPYRIDINE DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF VIRAL INFECTIONS | NOVARTIS AG (CH) | 2014-10-16 | — | — | WO | disclosed |