Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 3/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28013376 | 0.79 | CES2 (0.54) | MAPTKDM4EALDH1A1CYP3A4GAA | |
| Aminosalicylic Acid SCHEMBL9949357 | 0.78 | ALDH1A1 (0.92) | MAPTKDM4EALDH1A1CYP3A4GAA | |
| SCHEMBL1526264 | 0.77 | MAPT (0.69) | MAPTKDM4EALDH1A1CYP3A4GAA | |
| SCHEMBL23176329 | 0.76 | PLAU (0.43) | MAPTKDM4EALDH1A1CYP3A4GAA | |
| SCHEMBL27758947 | 0.76 | ALDH1A1 (0.50) | MAPTKDM4EALDH1A1CYP3A4GAA | |
| SCHEMBL17826825 | 0.76 | ERN1 (0.36) | MAPTKDM4EALDH1A1CYP3A4GAA | |
| SCHEMBL5746471 | 0.76 | CA3 (0.48) | ALDH1A1ESR2PLAULMNASMN1; SMN2 | |
| SCHEMBL24314179 | 0.76 | C1S (0.45) | MAPTKDM4EGAACASP1PLAU | |
| SCHEMBL5260076 | 0.76 | F2 (0.55) | MAPTALDH1A1GAATDP1PLAU | |
| SCHEMBL13448267 | 0.76 | PLAU (0.55) | MAPTKDM4EALDH1A1CYP3A4TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2978750-A2 | \"SYNTHESIS OF DABIGATRAN\ | USV Limited (IN) | 2016-02-03 | — | — | EP | claimed |
| WO-2014167577-A2 | \"SYNTHESIS OF DABIGATRAN\ | USV LIMITED (IN) | 2014-10-16 | — | — | WO | claimed |
| CN-105523999-B | Synthesis method of dabigatran etexilate intermediate | 重庆医药工业研究院有限责任公司 | 2020-04-24 | — | — | CN | disclosed |
| EP-2978750-A2 | \"SYNTHESIS OF DABIGATRAN\ | USV Limited (IN) | 2016-02-03 | — | — | EP | disclosed |
| WO-2014167577-A2 | \"SYNTHESIS OF DABIGATRAN\ | USV LIMITED (IN) | 2014-10-16 | — | — | WO | disclosed |