Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 6/20 | 0.51 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.51 |
| ▸ | BTK | Q06187 | 2/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.42 |
| ▸ | PARP15 | Q460N3 | 3/20 | 0.42 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.42 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.42 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800757 | 0.93 | TNK2 (0.49) | PARP10TNK2BTKPARP15SCN9A | |
| SCHEMBL18800753 | 0.92 | BTK (0.49) | TNK2BTKSCN9A | |
| SCHEMBL18800492 | 0.91 | BTK (0.48) | TNK2BTKSCN9A | |
| SCHEMBL18800616 | 0.90 | BTK (0.47) | TNK2BTKSCN9A | |
| SCHEMBL18800564 | 0.89 | BTK (0.47) | TNK2BTKALDH1A1KMT2ASCN9A | |
| SCHEMBL18800747 | 0.86 | KMT2A (0.46) | TNK2BTKALDH1A1KMT2A | |
| SCHEMBL18800583 | 0.86 | BTK (0.43) | PARP10TNK2BTKALDH1A1SCN9A | |
| SCHEMBL18800615 | 0.86 | BTK (0.62) | BTKKMT2A | |
| SCHEMBL18800755 | 0.85 | TNK2 (0.50) | TNK2BTKCHEK2F2 | |
| SCHEMBL18800556 | 0.84 | ATR (0.44) | PARP10BTKPARP14ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |
| EP-2789615-A1 | Azaindazoles as Btk kinase modulators and use thereof | Bristol-Myers Squibb Company (US) | 2014-10-15 | — | — | EP | disclosed |