Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 3/20 | 0.49 |
| ▸ | BTK | Q06187 | 3/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.42 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 2/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16168177 | 0.93 | PARP10 (0.51) | TNK2BTKPARP10PARP15FEN1 | |
| SCHEMBL18800753 | 0.92 | BTK (0.49) | TNK2BTKSCN9A | |
| SCHEMBL18800492 | 0.91 | BTK (0.48) | TNK2BTKSCN9A | |
| SCHEMBL18800616 | 0.90 | BTK (0.47) | TNK2BTKSCN9A | |
| SCHEMBL18800755 | 0.89 | TNK2 (0.50) | TNK2BTKMAP4K4 | |
| SCHEMBL18800564 | 0.89 | BTK (0.47) | TNK2BTKSCN9A | |
| SCHEMBL18800747 | 0.86 | KMT2A (0.46) | TNK2BTK | |
| SCHEMBL18800583 | 0.86 | BTK (0.43) | TNK2BTKPARP10SCN9A | |
| SCHEMBL18800615 | 0.86 | BTK (0.62) | BTK | |
| SCHEMBL18800556 | 0.84 | ATR (0.44) | BTKPARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |