Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.43 |
| ▸ | TNK2 | Q07912 | 9/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12875270 | 0.87 | GPR39 (0.39) | BTKTNK2SCN9A | |
| SCHEMBL18800658 | 0.81 | DHODH (0.41) | BTKTNK2NPC1RAB9ASCN9A | |
| SCHEMBL18800411 | 0.81 | BTK (0.56) | BTKTNK2NPC1RAB9ASCN9A | |
| SCHEMBL18800646 | 0.81 | BTK (0.43) | BTKTNK2NPC1RAB9ASCN9A | |
| SCHEMBL18800638 | 0.80 | DHPS (0.41) | TNK2NPC1RAB9ASCN9AADORA2A | |
| SCHEMBL18800669 | 0.79 | DCUN1D1 (0.32) | BTKSCN9A | |
| SCHEMBL18800729 | 0.76 | BTK (0.51) | BTKNPC1RAB9A | |
| SCHEMBL13977748 | 0.76 | BTK (0.35) | BTKTNK2SCN9A | |
| SCHEMBL16168182 | 0.75 | SCN9A (0.54) | NPC1RAB9ASCN9AADORA2A | |
| SCHEMBL18800780 | 0.74 | SCN9A (0.44) | BTKNPC1RAB9ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |